Department of Psychiatry & Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA.
Int J Eat Disord. 2012 Sep;45(6):812-5. doi: 10.1002/eat.22010. Epub 2012 Mar 12.
To investigate recruitment and retention for a randomized controlled trial (RCT) of adolescent anorexia nervosa (AN), as prior studies suggest that these are significant hurdles to completing meaningful RCTs in this population.
Retrospective analyses of recruitment and retention rates were conducted for a multisite RCT of family-based treatment (FBT) versus adolescent-focused therapy (AFT) recruiting adolescents between 12 and 18 years of age with AN.
Adolescent participants were recruited from a variety of both medical and nonmedical sources. Recruitment goals were met in time (October 2004-March 2007). Percent retention rates were high across both treatment types (84% for FBT and 92% for AFT), and these rates did not differ significantly.
These results reveal that recruitment and retention of adolescent patients with AN to RCTs are feasible in contrast to the experience in adult studies. It is likely that characteristics of our clinical programs make recruitment easier than in other settings, e.g., child and adolescent focused, specialized eating disorders program with an emphasis on outpatient treatment, recognized leaders in the field, and a history of clinical excellence with this population.
调查一项针对青少年厌食症（AN）的随机对照试验（RCT）的招募和保留情况，因为先前的研究表明，在这一人群中完成有意义的 RCT 存在重大障碍。
对一项多中心 RCT 进行回顾性分析，该 RCT 比较了家庭为基础的治疗（FBT）与青少年为焦点的治疗（AFT），招募年龄在 12 至 18 岁之间的患有 AN 的青少年。
青少年参与者来自各种医疗和非医疗来源。招募目标在规定时间内（2004 年 10 月至 2007 年 3 月）完成。两种治疗类型的保留率均较高（FBT 为 84%，AFT 为 92%），且差异无统计学意义。
这些结果表明，与成人研究的经验相反，招募和保留青少年 AN 患者参加 RCT 是可行的。我们的临床项目的特点可能使招募比其他环境更容易，例如，以儿童和青少年为重点、专注于门诊治疗的专门饮食失调症计划、该领域的知名领导者以及在该人群中具有卓越临床经验的历史。
