Patil Vikas V, Bhangale Shandavi C, Chaudhari Kundan P, Kakade Rajanikant T, Thakare Vinod M, Bonde Chandrakant G, Patil Vijay R
Department of Pharmaceutical Chemistry, Tapi Valley Education Society's Honorable Loksevak Madhukarrao, Chaudhari College of Pharmacy, Faizpur 425502, Maharashtra, India.
Zhong Xi Yi Jie He Xue Bao. 2012 Mar;10(3):347-52. doi: 10.3736/jcim20120315.
The Khandesh region of Jalgaon district, India has a dense forest with plenty of medicinal plants which have been used as folklore medicines by the local people for many years. They use different parts of Ficus species to treat and cure diarrhea. Depending on the traditional use of some plants as antidiarrheal by local people of that region, the authors have selected three plants (specific parts) to evaluate their antidiarrheal activities in different animal models.
Wistar albino rats weighing 180 to 200 g of either sex were used in this study. There were eight groups for each individual study with 10 animals in each group. The antidiarrheal profile of the ethanolic extracts of the bark of Ficus bengalensis and the leaves of Ficus racemosa and Ficus carica from the region of Khandesh in Jalgaon district of Maharashtra, India were evaluated by different experimental models, namely, castor oil-induced diarrhea, gastrointestinal motility test, prostaglandin E₂ (PGE₂)-induced enteropooling in Wistar albino rats.
The extracts of F. bengalensis (bark), F. racemosa (leaves) and F. carica (leaves) showed significant inhibitory activities against castor oil-induced diarrhea and PGE2-induced enteropooling in rats. The ethanolic extracts at 400 and 600 mg/kg significantly inhibited diarrhea. There was a significant dose-dependent decrease in diarrhea produced by all the three models in rats as compared to that of the standard drug group (P<0.01). Based on the results in experimental rat models, the ethanolic extract of Ficus species demonstrated significant reductions in faecal output and frequency of droppings when compared to the castor oil-treated rats (P<0.01). All plant extracts also significantly retarded the propulsion of charcoal meal and significantly inhibited PGE(2)-induced enteropooling.
All these plant materials can be claimed as potential antidiarrheal agents. The underlying mechanism appears to be spasmolytic and an anti-enteropooling property by which the different plant extracts produced relief in diarrhea. Tannins and flavonoids present in the plant extracts may be responsible for the antidiarrheal activity.
印度贾尔冈区的坎德什地区有一片茂密的森林，生长着大量药用植物，多年来一直被当地人用作民间药物。他们使用榕属植物的不同部位来治疗腹泻。根据该地区当地人将某些植物传统用作止泻药的情况，作者挑选了三种植物（特定部位），在不同动物模型中评估它们的止泻活性。
本研究使用体重180至200克的Wistar白化大鼠，雌雄不限。每项单独研究分为八组，每组10只动物。通过不同实验模型，即蓖麻油诱导的腹泻、胃肠动力试验、前列腺素E₂（PGE₂）诱导的Wistar白化大鼠肠积液，评估印度马哈拉施特拉邦贾尔冈区坎德什地区孟加拉榕树皮、总状榕叶和无花果叶乙醇提取物的止泻情况。
孟加拉榕（树皮）、总状榕（叶）和无花果（叶）的提取物对大鼠蓖麻油诱导的腹泻和PGE₂诱导的肠积液显示出显著的抑制活性。400和600毫克/千克的乙醇提取物显著抑制腹泻。与标准药物组相比，所有三种模型在大鼠中产生的腹泻均有显著的剂量依赖性降低（P<0.01）。基于实验大鼠模型的结果，与蓖麻油处理的大鼠相比，榕属植物的乙醇提取物显示粪便排出量和排便频率显著降低（P<0.01）。所有植物提取物还显著延缓了炭末推进，并显著抑制了PGE₂诱导的肠积液。
所有这些植物材料都可被认为是潜在的止泻剂。其潜在机制似乎是解痉和抗肠积液特性，不同植物提取物通过该特性缓解腹泻。植物提取物中存在的单宁和黄酮类化合物可能是止泻活性的原因。
