Department for Nanostructured Materials, Jožef Stefan Institute, Ljubljana, Slovenia.
Int Orthop. 2012 Aug;36(8):1739-45. doi: 10.1007/s00264-012-1520-y. Epub 2012 Mar 16.
The aim of the study was to verify the ability of nanoparticulate bioactive glass (BAG) to infiltrate into the porous titanium (Ti) layer on Ti-based implants to promote osseointegration.
The porous titanium layer on Ti-based implants was impregnated with nanoparticulate BAG. The implants without or with BAG were implanted bilaterally in tibial holes of ten New Zealand white rabbits. The rabbits were sacrificed after ten weeks for examinations. Beside histological examination, EDXS analysis of polished cross-sections of explanted implants was also performed with the aim to quantitatively evaluate the bone-to-pore contact and bone-in-pore ratio.
After ten weeks, EDXS analyses of cross-sections of the explanted implants confirmed that bioactive glass was fully resorbed and that the pores throughout the thickness of the porous titanium layer were to a large extent filled with a new bone. In the absence of bioactive glass, only the outer part of the porous layer was filled with bone. The implants without BAG in the porous Ti-layer exhibited similar bone-to-pore contact, while significant improvement of bone ingrowth into the pores was observed for the implants with BAG (38%), as opposed to those without it (22%).
This study confirmed that the nanoparticulate bioactive glass within the porous titanium surface layer on implants promotes osseointegration and stimulates the formation of bone within the pores.
本研究旨在验证纳米生物活性玻璃（BAG）渗透到钛基植入物多孔钛层以促进骨整合的能力。
将纳米生物活性玻璃注入钛基植入物的多孔钛层中。将无 BAG 和有 BAG 的植入物分别双侧植入 10 只新西兰白兔的胫骨孔中。10 周后处死兔子进行检查。除组织学检查外，还对植入物的抛光横截面进行 EDXS 分析，目的是定量评估骨-孔接触和骨-孔比。
10 周后，对植入物横截面的 EDXS 分析证实，生物活性玻璃已完全吸收，多孔钛层整个厚度的孔已在很大程度上被新骨填充。在没有生物活性玻璃的情况下，只有多孔层的外部分被骨填充。在没有 BAG 的多孔 Ti 层中的植入物表现出相似的骨-孔接触，而对于有 BAG（38%）的植入物，骨向孔内生长有显著改善，而没有 BAG 的植入物则没有（22%）。
本研究证实，植入物表面多孔钛层内的纳米生物活性玻璃促进了骨整合，并刺激了骨在孔内的形成。
