Gil-Prieto Ruth, San Martín María, de Andrés Ana López, Alvaro-Meca Alejandro, González Antonio, de Miguel Angel Gil
Preventive Medicine & Public Health Department, Rey Juan Carlos University, Alcorcón, Madrid, Spain.
Hum Vaccin. 2009 Nov;5(11):748-53. doi: 10.4161/hv.5.11.9792. Epub 2009 Nov 12.
To analyze the epidemiology and burden of rotavirus infections amongst hospitalized children up to 5 years of age in Spain over a 10-year period (1998-2007).
During the study period (1998-2007), a total of 10,990 cases of rotavirus disease mentioned as a secondary diagnosis were recorded (annual incidence of 59.02 cases per 100,000 people and 0.45 cases per 100 admissions). The average patient age was 9.8 months (SD 9.3), with 71% of the patients younger than 12 months of age. The mortality rate for children hospitalized for other primary causes, with rotavirus gastroenteritis as a secondary diagnosis was 0.16 per 100,000, and the case-fatality rate was 0.27%. The hospitalization rate decreased significantly with age, from 226 cases per 100,000 children 12 months of age or younger to 1.78 cases per 100,000 in children at the age of four. The infection rate amongst hospitalized children also decreased significantly with age, from 0.55% and 0.66% in children under one and two years, respectively, to 0.04% in children at the age of four.
Data provided by the National Epidemiology Surveillance System for Hospital Data (Conjunto Mínimo Básico de Datos; CMBD) were analyzed. This database includes clinical information on hospitalizations and associated costs. For the purpose of this study, hospital discharges that mentioned rotavirus disease as a secondary diagnosis (ICD-9CM 008.61) were considered rotavirus hospital-acquired infections. All such cases reported from January 1, 1998 to December 31, 2007 were selected.
Hospital-acquired rotavirus infection morbidity and the associated consumption of health care resources are still important in Spain, especially in the younger groups (24 months of age and younger).
分析西班牙10年间（1998 - 2007年）5岁以下住院儿童轮状病毒感染的流行病学特征及负担。
在研究期间（1998 - 2007年），共记录了10990例作为次要诊断提及的轮状病毒病病例（年发病率为每10万人59.02例，每100例住院中有0.45例）。患者平均年龄为9.8个月（标准差9.3），71%的患者年龄小于12个月。因其他主要原因住院且轮状病毒胃肠炎作为次要诊断的儿童死亡率为每10万人0.16例，病死率为0.27%。住院率随年龄显著下降，从12个月及以下儿童每10万人226例降至4岁儿童每10万人1.78例。住院儿童的感染率也随年龄显著下降，从1岁以下儿童的0.55%和2岁以下儿童的0.66%分别降至4岁儿童的0.04%。
分析了国家医院数据流行病学监测系统（最小基本数据库；CMBD）提供的数据。该数据库包括住院临床信息及相关费用。本研究将提及轮状病毒病作为次要诊断（国际疾病分类第九版临床修订本008.61）的出院病例视为医院获得性轮状病毒感染。选取了1998年1月1日至2007年12月31日报告的所有此类病例。
在西班牙，医院获得性轮状病毒感染发病率及相关医疗资源消耗仍然很重要，尤其是在较年轻群体（24个月及以下）中。
