College of Pharmacy, Chungbuk National University, 12 Gaesin-dong, Heungduk-gu, Cheongju, Chungbuk, 361-763, Korea.
Phytother Res. 2012 Dec;26(12):1884-92. doi: 10.1002/ptr.4643. Epub 2012 Mar 19.
Alzheimer's disease (AD) is the most common form of dementia and is characterized by deposition of amyloid beta (Aβ) in the brain. The components of the herb Magnolia officinalis are known to have antiinflammatory, antioxidative and neuroprotective activities. In this study we investigated the effects of ethanol extract of M. officinalis on memory dysfunction and amyloidogenesis in a transgenic mouse model of AD. Oral pretreatment of ethanol extract of M. officinalis (10 mg/kg in 0.05% ethanol) into drinking water for 3 months inhibited memory impairment and Aβ deposition in the brain of Tg2576 mice. Ethanol extract of M. officinalis also decreased activity of β-secretase, cleaving Aβ from amyloid precursor protein (APP), and expression of β-site APP cleaving enzyme 1 (BACE1), APP and its product, C99. Our results showed that ethanol extract of M. officinalis effectively prevented memory impairment via down-regulating β-secretase activity.
阿尔茨海默病（AD）是最常见的痴呆症形式，其特征是大脑中淀粉样β（Aβ）的沉积。众所周知，厚朴的成分具有抗炎、抗氧化和神经保护作用。在这项研究中，我们研究了厚朴乙醇提取物对 AD 转基因小鼠模型中记忆功能障碍和淀粉样蛋白形成的影响。厚朴乙醇提取物（10mg/kg 在 0.05%乙醇中）经口预处理 3 个月，可抑制 Tg2576 小鼠的记忆障碍和大脑中的 Aβ沉积。厚朴乙醇提取物还降低了β-分泌酶的活性，β-分泌酶可将 Aβ从淀粉样前体蛋白（APP）中切割出来，并降低β-位点 APP 切割酶 1（BACE1）、APP 及其产物 C99 的表达。我们的结果表明，厚朴乙醇提取物通过下调β-分泌酶活性有效预防了记忆障碍。
