Department of Neurology, En Chu Kong Hospital, Sanxia District, New Taipei City, Taiwan.
Diabetes Care. 2012 May;35(5):1047-9. doi: 10.2337/dc11-1511. Epub 2012 Mar 19.
We retrospectively assessed the age- and sex-specific incidence and relative risk of Parkinson disease (PD) in Taiwan's diabetic population.
Study cohort included 603,416 diabetic patients and 472,188 nondiabetic control subjects. Incidence rate and relative risk of PD (ICD-9-CM 332.0) were evaluated.
The incidence of PD was 3.59 and 2.15 per 10,000 person-years for the diabetic and control group, respectively, representing a covariate adjusted hazard ratio (HR) of 1.61 (95% CI 1.56-1.66), which was substantially reduced to 1.37 (1.32-1.41) after adjusting for medical visits. Diabetes was associated with a significantly elevated risk of PD in all sex and age stratifications except in young women, with the highest HR noted for young men aged 21-40 years (2.10 [1.01-4.42]), followed by women aged 41-60 (2.05 [1.82-2.30]) and >60 years (1.65 [1.58-1.73]).
Diabetes is associated with an increased risk of PD onset in a Chinese population, and the relation is stronger in women and younger patients.
我们回顾性评估了台湾地区糖尿病患者中帕金森病（PD）的年龄和性别特异性发病率和相对风险。
研究队列包括 603416 例糖尿病患者和 472188 例非糖尿病对照者。评估了 PD 的发病率和相对风险（ICD-9-CM 332.0）。
PD 的发病率在糖尿病组和对照组中分别为 3.59 和 2.15/10000 人年，校正后的风险比（HR）为 1.61（95%CI 1.56-1.66），调整就诊后显著降低至 1.37（1.32-1.41）。除年轻女性外，糖尿病与 PD 风险显著升高相关，在所有性别和年龄分层中，21-40 岁的年轻男性风险最高（2.10[1.01-4.42]），其次是 41-60 岁的女性（2.05[1.82-2.30]）和>60 岁的女性（1.65[1.58-1.73]）。
在中国人中，糖尿病与 PD 发病风险增加相关，且在女性和年轻患者中更为显著。
