1 型糖尿病妊娠患者的胰岛素需求：双胎妊娠患者需要的胰岛素是单胎妊娠患者的两倍吗？
Insulin requirements in type 1 diabetic pregnancy: do twin pregnant women require twice as much insulin as singleton pregnant women?
机构信息
Center for PregnantWomen with Diabetes, Rigshospitalet, Copenhagen, Denmark.
出版信息
Diabetes Care. 2012 Jun;35(6):1246-8. doi: 10.2337/dc11-2467. Epub 2012 Mar 19.
OBJECTIVE
To evaluate the insulin requirements in women with type 1 diabetes during twin pregnancy compared with singleton pregnancy.
RESEARCH DESIGN AND METHODS
At 8, 14, 21, 27, and 33 gestational weeks, insulin requirements and HbA(1c) were compared between 15 twin pregnant women from 2000 to 2011 and 108 singleton pregnant women from 2004 to 2006.
RESULTS
In twin pregnancies, the weekly increase in daily insulin dose between 14 and 27 weeks was higher than in singleton pregnancies (median 3.0 international units [IU] [range 0.9-4.9] versus 1.5 IU [-1.5 to 5.9]; P = 0.008) and remained stable from 27 to 33 weeks. The increment in total insulin requirement from before pregnancy until 33 weeks tended to be higher in twin pregnancies (103% [36-257%] versus 71% [-20 to 276%]; P = 0.07). Throughout pregnancy, HbA(1c) was similar in twin and singleton pregnancies.
CONCLUSIONS
In twin pregnancies, the weekly increase in insulin dose between 14 and 27 weeks was doubled compared with singleton pregnancies.
目的
评估 1 型糖尿病女性在双胎妊娠期间与单胎妊娠期间的胰岛素需求。
研究设计和方法
在 2000 年至 2011 年期间，对 15 名双胎妊娠妇女和 2004 年至 2006 年期间的 108 名单胎妊娠妇女，在妊娠 8、14、21、27 和 33 周时比较了胰岛素需求和 HbA(1c)。
结果
在双胎妊娠中，14 至 27 周之间每日胰岛素剂量的每周增加量高于单胎妊娠（中位数 3.0 国际单位[IU] [0.9-4.9] 与 1.5 IU [-1.5-5.9]；P = 0.008），并从 27 周到 33 周保持稳定。从妊娠前到 33 周，双胎妊娠中总胰岛素需求的增量趋于更高（103% [36-257%] 与 71% [-20-276%]；P = 0.07）。整个妊娠期间，双胎妊娠和单胎妊娠的 HbA(1c)相似。
结论
在双胎妊娠中，14 至 27 周之间胰岛素剂量的每周增加量是单胎妊娠的两倍。
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