Antel J P, Arnason B G, Fuller T C, Lehrich J R
Arch Neurol. 1976 Jun;33(6):423-5. doi: 10.1001/archneur.1976.00500060029007.
Histocompatibility (HL-A) phenotypes of 44 unrelated white patients from the greater Boston area with amyotrophic lateral sclerosis (ALS) and 200 white controls were compared. In the overall ALS group, an increased frequency of HL-A3 was noted (43% vs 25%, P less than .05). Thirty-eight patients had rapidly progressive disease; among this group the HL-A3 incidence was 50% (P less than .005). Six patients had slowly progressive disease, none had HL-A3, and five had HL-A12. The HL-A antigens may link with disease severity in ALS.
对来自大波士顿地区的44例患肌萎缩侧索硬化症（ALS）的非亲属白人患者和200例白人对照者的组织相容性（HL-A）表型进行了比较。在整个ALS组中，发现HL-A3的频率增加（43%对25%，P<0.05）。38例患者患有快速进展性疾病；在该组中，HL-A3的发生率为50%（P<0.005）。6例患者患有缓慢进展性疾病，无一例有HL-A3，5例有HL-A12。HL-A抗原可能与ALS的疾病严重程度相关。
