Wollmer P, Schairer W, Bos J A, Bakker W, Krenning E P, Lachmann B
Department of Anaesthesiology, Erasmus University, Rotterdam, The Netherlands.
Acta Anaesthesiol Scand. 1990 Oct;34(7):572-5. doi: 10.1111/j.1399-6576.1990.tb03147.x.
We studied the integrity of the alveolo-capillary barrier during different forms of anaesthesia by measuring the pulmonary clearance of inhaled 99mTc-DTPA. We studied four groups of rabbits. Groups I and II were anaesthetized with nembuthal only and the fractional concentration of inspired oxygen (F1O2) was 0.30 and 1.00, respectively. Groups III and IV were anaesthetized with 1% halothane and F1O2 was 0.30 and 0.99, respectively. 99mTc-DTPA was administered as a fine aerosol and the clearance of the tracer from the lungs was subsequently measured with a gamma camera. The mean half-life of the tracer in the lungs in Groups I-IV was 60, 58, 59 and 26 min, respectively. The rapid pulmonary clearance of 99mTc-DTPA in Group IV indicates that halothane in combination with high oxygen concentration increases the permeability of the alveolo-capillary barrier. This may be due to effects on the pulmonary surfactant system and/or the alveolar epithelium.
我们通过测量吸入的99mTc-DTPA的肺清除率，研究了不同麻醉方式下肺泡-毛细血管屏障的完整性。我们研究了四组兔子。第一组和第二组仅用戊巴比妥麻醉，吸入氧分数（F1O2）分别为0.30和1.00。第三组和第四组用1%氟烷麻醉，F1O2分别为0.30和0.99。99mTc-DTPA以细气溶胶形式给药，随后用γ相机测量示踪剂从肺部的清除率。第一至四组示踪剂在肺部的平均半衰期分别为60、58、59和26分钟。第四组中99mTc-DTPA的快速肺清除表明，氟烷与高氧浓度联合使用会增加肺泡-毛细血管屏障的通透性。这可能是由于对肺表面活性物质系统和/或肺泡上皮的影响。
