酒精、烟草和大麻联合使用的主观效应与交叉药物结局的关系。
Subjective effects for alcohol, tobacco, and marijuana association with cross-drug outcomes.
机构信息
Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309-0447, USA.
出版信息
Drug Alcohol Depend. 2012 Jun;123 Suppl 1(0 1):S52-8. doi: 10.1016/j.drugalcdep.2012.02.014. Epub 2012 Mar 22.
METHODS
The cross-drug relationship of subjective experiences between alcohol, tobacco, and marijuana and problem drug use behaviors were examined. Data were drawn from 3853 individuals between the ages of 11 and 30 years of age participating in the Colorado Center on Antisocial Drug Dependence [CADD]. Subjective experiences were assessed using a 13-item questionnaire that included positive and negative responses for alcohol, tobacco, and marijuana. Lifetime abuse and dependence on these three drugs was assessed using the Composite International Diagnostic Interview, Substance Abuse Module [CIDI-SAM].
RESULTS
Positive and negative subjective experience scales were similar for alcohol, tobacco, and marijuana, although the hierarchical ordering of items differed by drug. Subjective experience scales for each of the three drugs examined correlated significantly, with the strongest relationship being for alcohol and marijuana experiences. Significant associations were identified between how a person experienced a drug and abuse and dependence status for the same or different drug.
CONCLUSION
Cross-drug relationships provide evidence for a common liability or sensitivity towards responding in a similar manner to drugs of abuse within and across different pharmacological classes.
方法
考察了酒精、烟草和大麻之间的交叉药物关系以及药物使用问题行为。数据来自科罗拉多反社会药物依赖中心（CADD）的 3853 名年龄在 11 至 30 岁之间的个体。使用包括酒精、烟草和大麻的正性和负性反应的 13 项问卷评估主观体验。使用复合国际诊断访谈，物质滥用模块（CIDI-SAM）评估这三种药物的终生滥用和依赖。
结果
尽管药物的项目排序不同，但酒精、烟草和大麻的正性和负性主观体验量表相似。三种药物的主观体验量表之间存在显著相关性，酒精和大麻体验之间的关系最强。一个人对一种药物的体验与相同或不同药物的滥用和依赖状态之间存在显著关联。
结论
跨药物关系为对不同药理学类别中的滥用药物以相似方式反应的共同倾向或敏感性提供了证据。
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