Staroverov S A, Vidyasheva I V, Gabalov K P, Vasilenko O A, Laskavyi V N, Dykman L A
Institute of Plant and Microorganism Biochemistry and Physiology, Russian Academy of Sciences, Saratov, Russia.
Bull Exp Biol Med. 2011 Aug;151(4):436-9. doi: 10.1007/s10517-011-1350-8.
Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respiratory activity and of plasma IFN-γ level in immunized animals.
用与金纳米颗粒偶联的传染性胃肠炎病毒对动物进行免疫。所得抗体的效价比针对天然病毒产生的抗体更高。用抗原 - 胶体金复合物免疫导致免疫动物的腹腔巨噬细胞呼吸活性和血浆干扰素 -γ水平显著增加。
