Xu Chun, Lei Chang, Hosseinpour Sepanta, Ivanovski Saso, Walsh Laurence J, Khademhosseini Ali
School of Dentistry, The University of Queensland, Brisbane 4006, Australia.
Centre for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3), School of Dentistry, The University of Queensland, Brisbane 4006, Australia.
Natl Sci Rev. 2022 Jun 27;9(10):nwac124. doi: 10.1093/nsr/nwac124. eCollection 2022 Oct.
Following the global COVID-19 pandemic, nanotechnology has been at the forefront of research efforts and enables the fast development of diagnostic tools, vaccines and antiviral treatment for this novel virus (SARS-CoV-2). In this review, we first summarize nanotechnology with regard to the detection of SARS-CoV-2, including nanoparticle-based techniques such as rapid antigen testing, and nanopore-based sequencing and sensing techniques. Then we investigate nanotechnology as it applies to the development of COVID-19 vaccines and anti-SARS-CoV-2 nanomaterials. We also highlight nanotechnology for the post-pandemic era, by providing tools for the battle with SARS-CoV-2 variants and for enhancing the global distribution of vaccines. Nanotechnology not only contributes to the management of the ongoing COVID-19 pandemic but also provides platforms for the prevention, rapid diagnosis, vaccines and antiviral drugs of possible future virus outbreaks.
在全球新冠疫情之后,纳米技术一直处于研究工作的前沿,并推动了针对这种新型病毒(严重急性呼吸综合征冠状病毒2,SARS-CoV-2)的诊断工具、疫苗和抗病毒治疗的快速发展。在本综述中,我们首先总结了纳米技术在检测SARS-CoV-2方面的应用,包括基于纳米颗粒的技术,如快速抗原检测,以及基于纳米孔的测序和传感技术。然后,我们研究了纳米技术在新冠疫苗和抗SARS-CoV-2纳米材料开发中的应用。我们还强调了纳米技术在大流行后时代的作用,通过提供应对SARS-CoV-2变异株的工具和加强疫苗的全球分发来实现。纳米技术不仅有助于应对当前的新冠疫情,还为未来可能的病毒爆发提供预防、快速诊断、疫苗和抗病毒药物的平台。