胞质钙振荡器的计算机模拟。
Computer simulation of a cytosolic calcium oscillator.
作者信息
Swillens S, Mercan D
机构信息
Institut de Recherche Interdisciplinaire, Université Libre de Bruxelles, Belgium.
出版信息
Biochem J. 1990 Nov 1;271(3):835-8. doi: 10.1042/bj2710835.
Abstract
A new interpretation of existing data permits us to define a model capable of accounting for agonist-induced Ca2+ oscillations in the cytosol of electrically non-excitable cells. The model only requires one Ca2+ store, which contains Ca2+ channels controlled by inositol 1,4,5-trisphosphate and Ca2+. Computer simulations may generate different experimentally observed patterns of Ca2+ oscillations.
摘要
对现有数据的一种新解释使我们能够定义一个模型，该模型能够解释在电非兴奋性细胞胞质溶胶中激动剂诱导的Ca2+振荡。该模型仅需要一个Ca2+储存库，其中包含由肌醇1,4,5-三磷酸和Ca2+控制的Ca2+通道。计算机模拟可以生成不同的实验观察到的Ca2+振荡模式。
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