血清和滑液中 MIF 与膝关节骨关节炎严重程度的相关性。
Association of MIF in serum and synovial fluid with severity of knee osteoarthritis.
机构信息
Department of Trauma, Union Medicine Centre, Tianjin, PR China.
出版信息
Clin Biochem. 2012 Jul;45(10-11):737-9. doi: 10.1016/j.clinbiochem.2012.03.012. Epub 2012 Mar 16.
OBJECTIVE
Recent evidences suggest that inflammation contributes to the development and progression of osteoarthritis (OA). This study aims to determine macrophage migration inhibitory factor (MIF) levels in serum and synovial fluid (SF) of patients with knee OA and to analyze the association of MIF levels with the radiographic severity of OA.
DESIGN AND METHODS
224 patients with knee OA and 186 healthy controls were enrolled in this study.
RESULTS
Higher levels of serum MIF were found in knee OA patients compared with healthy controls. Knee OA patients with Kellgren and Lawrence (KL) grade 4 showed significantly elevated MIF levels in serum and SF compared with those with KL grade 2 and 3. MIF levels in serum and SF of knee OA patients were significantly related to disease severity evaluated by KL grading criteria.
CONCLUSION
MIF levels in serum and SF were closely related to the radiographic severity of OA.
目的
最近的证据表明，炎症参与了骨关节炎（OA）的发生和发展。本研究旨在测定膝骨关节炎（OA）患者血清和滑液（SF）中巨噬细胞移动抑制因子（MIF）的水平，并分析 MIF 水平与 OA 放射学严重程度的相关性。
设计和方法
本研究纳入了 224 例膝 OA 患者和 186 例健康对照者。
结果
与健康对照组相比，膝 OA 患者的血清 MIF 水平更高。Kellgren 和 Lawrence（KL）分级 4 的膝 OA 患者的血清和 SF 中 MIF 水平明显高于 KL 分级 2 和 3 的患者。血清和 SF 中的 MIF 水平与 KL 分级标准评估的疾病严重程度显著相关。
结论
血清和 SF 中的 MIF 水平与 OA 的放射学严重程度密切相关。
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