University Institute of Geriatrics of Sherbrooke, Quebec, Canada.
J Aging Health. 2012 Aug;24(5):812-26. doi: 10.1177/0898264312440324. Epub 2012 Mar 26.
To investigate the additive effect of dynapenia and abdominal obesity on metabolic risk factors in older adults.
A total of 3,007 men and women from the National Health and Nutrition Examination Survey (NHANES) study were categorized as follows: (a) non-dynapenic/non-abdominally obese (N-DYN/N-AO), (b) dynapenic/non-abdominally obese (DYN/N-AO), (c) non-dynapenic/abdominally obese (N-DYN/AO), (d) dynapenic/ abdominally obese (DYN/AO) based on waist circumference (WC) and leg muscle strength tertiles. Dependent variables were lipids, glucose, blood pressure, and other chronic conditions.
The DYN/AO group had lower plasma HDL-chol and higher triglyceride and glucose levels than N-DYN/N-AO and DYN/N-AO groups (all p ≤ .01). Higher plasma triglyceride was observed in the DYN/AO group compared with N-DYN/AO group (p ≤ .01). The odds of having metabolic syndrome, cardiovascular diseases, and type II diabetes were higher in DYN/AO compared with DYN/N-AO and N-DYN/N-AO.
DYN/AO older adults might be at greater risk of metabolic alterations than those displaying dynapenia alone or those with neither abdominal obesity nor dynapenia.
研究老年人肌肉减少症和腹型肥胖对代谢危险因素的联合作用。
本研究共纳入了来自国家健康和营养调查（NHANES）研究的 3007 名男性和女性，他们被分为以下几类：（a）非肌肉减少症/非腹型肥胖（N-DYN/N-AO），（b）肌肉减少症/非腹型肥胖（DYN/N-AO），（c）非肌肉减少症/腹型肥胖（N-DYN/AO），（d）肌肉减少症/腹型肥胖（DYN/AO），分类依据为腰围（WC）和腿部肌肉力量三分位数。因变量为血脂、血糖、血压和其他慢性疾病。
与 N-DYN/N-AO 和 DYN/N-AO 组相比，DYN/AO 组的血浆高密度脂蛋白胆固醇（HDL-chol）水平较低，甘油三酯和血糖水平较高（均 p≤0.01）。与 N-DYN/AO 组相比，DYN/AO 组的血浆甘油三酯水平更高（p≤0.01）。与 DYN/N-AO 组和 N-DYN/N-AO 组相比，DYN/AO 组发生代谢综合征、心血管疾病和 2 型糖尿病的几率更高。
与仅存在肌肉减少症或既无腹型肥胖也无肌肉减少症的老年人相比，同时存在肌肉减少症和腹型肥胖的老年人可能面临更大的代谢异常风险。
