50 岁及以上成年人的 Dynapenic 腹部肥胖和代谢危险因素。

Dynapenic abdominal obesity and metabolic risk factors in adults 50 years of age and older.

机构信息

University Institute of Geriatrics of Sherbrooke, Quebec, Canada.

出版信息

J Aging Health. 2012 Aug;24(5):812-26. doi: 10.1177/0898264312440324. Epub 2012 Mar 26.

DOI:10.1177/0898264312440324

PMID:22451528

Abstract

OBJECTIVES

To investigate the additive effect of dynapenia and abdominal obesity on metabolic risk factors in older adults.

METHOD

A total of 3,007 men and women from the National Health and Nutrition Examination Survey (NHANES) study were categorized as follows: (a) non-dynapenic/non-abdominally obese (N-DYN/N-AO), (b) dynapenic/non-abdominally obese (DYN/N-AO), (c) non-dynapenic/abdominally obese (N-DYN/AO), (d) dynapenic/ abdominally obese (DYN/AO) based on waist circumference (WC) and leg muscle strength tertiles. Dependent variables were lipids, glucose, blood pressure, and other chronic conditions.

RESULTS

The DYN/AO group had lower plasma HDL-chol and higher triglyceride and glucose levels than N-DYN/N-AO and DYN/N-AO groups (all p ≤ .01). Higher plasma triglyceride was observed in the DYN/AO group compared with N-DYN/AO group (p ≤ .01). The odds of having metabolic syndrome, cardiovascular diseases, and type II diabetes were higher in DYN/AO compared with DYN/N-AO and N-DYN/N-AO.

CONCLUSION

DYN/AO older adults might be at greater risk of metabolic alterations than those displaying dynapenia alone or those with neither abdominal obesity nor dynapenia.

摘要

目的

研究老年人肌肉减少症和腹型肥胖对代谢危险因素的联合作用。

方法

本研究共纳入了来自国家健康和营养调查（NHANES）研究的 3007 名男性和女性，他们被分为以下几类：（a）非肌肉减少症/非腹型肥胖（N-DYN/N-AO），（b）肌肉减少症/非腹型肥胖（DYN/N-AO），（c）非肌肉减少症/腹型肥胖（N-DYN/AO），（d）肌肉减少症/腹型肥胖（DYN/AO），分类依据为腰围（WC）和腿部肌肉力量三分位数。因变量为血脂、血糖、血压和其他慢性疾病。

结果

与 N-DYN/N-AO 和 DYN/N-AO 组相比，DYN/AO 组的血浆高密度脂蛋白胆固醇（HDL-chol）水平较低，甘油三酯和血糖水平较高（均 p≤0.01）。与 N-DYN/AO 组相比，DYN/AO 组的血浆甘油三酯水平更高（p≤0.01）。与 DYN/N-AO 组和 N-DYN/N-AO 组相比，DYN/AO 组发生代谢综合征、心血管疾病和 2 型糖尿病的几率更高。