New England Research Institutes, Watertown, Massachusetts, USA.
Pediatrics. 2012 Apr;129(4):630-8. doi: 10.1542/peds.2011-1419. Epub 2012 Mar 26.
To test the hypothesis that the profile of sudden infant death syndrome (SIDS) changed after the Back-to-Sleep (BTS) campaign initiation, document prevalence and patterns of multiple risks, and determine the age profile of risk factors.
The San Diego SIDS/Sudden Unexplained Death in Childhood Research Project recorded risk factors for 568 SIDS deaths from 1991 to 2008 based upon standardized death scene investigations and autopsies. Risks were divided into intrinsic (eg, male gender) and extrinsic (eg, prone sleep).
Between 1991-1993 and 1996-2008, the percentage of SIDS infants found prone decreased from 84.0% to 48.5% (P < .001), bed-sharing increased from 19.2% to 37.9% (P < .001), especially among infants <2 months (29.0% vs 63.8%), prematurity rate increased from 20.0% to 29.0% (P = .05), whereas symptoms of upper respiratory tract infection decreased from 46.6% to 24.8% (P < .001). Ninety-nine percent of SIDS infants had at least 1 risk factor, 57% had at least 2 extrinsic and 1 intrinsic risk factor, and only 5% had no extrinsic risk. The average number of risks per SIDS infant did not change after initiation of the BTS campaign.
SIDS infants in the BTS era show more variation in risk factors. There was a consistently high prevalence of both intrinsic and especially extrinsic risks both before and during the Back-to-Sleep era. Risk reduction campaigns emphasizing the importance of avoiding multiple and simultaneous SIDS risks are essential to prevent SIDS, including among infants who may already be vulnerable.
检验“仰卧睡眠(Back-to-Sleep,BTS)”宣传活动开展后婴儿猝死综合征(Sudden Infant Death Syndrome,SIDS)病例特征发生改变的假说,记录多种危险因素的现患率和模式,并确定危险因素的年龄特征。
圣地亚哥 SIDS/儿童突发性不明原因死亡研究项目对 1991 年至 2008 年间 568 例 SIDS 死亡病例进行了危险因素调查,调查基于标准化的死亡现场调查和尸检。危险因素分为内在(如,男性)和外在(如,俯卧位睡眠)两类。
1991-1993 年与 1996-2008 年相比,俯卧位睡眠的 SIDS 婴儿比例从 84.0%降至 48.5%(P<0.001),同床睡眠比例从 19.2%增至 37.9%(P<0.001),尤其是 2 个月以下婴儿(29.0%比 63.8%);早产儿比例从 20.0%增至 29.0%(P=0.05),而上呼吸道感染症状比例从 46.6%降至 24.8%(P<0.001)。99%的 SIDS 婴儿存在至少 1 种危险因素,57%存在至少 2 种外在危险因素和 1 种内在危险因素,仅有 5%无外在危险因素。BTS 宣传活动开展后,SIDS 婴儿的平均危险因素数量未发生变化。
BTS 时代的 SIDS 婴儿的危险因素变化更大。无论在 BTS 时代之前还是之后,内在和外在危险因素的普遍高发生率都保持一致。宣传活动强调避免多种和同时存在的 SIDS 危险因素的重要性,对于预防 SIDS 至关重要,包括那些可能已经处于脆弱状态的婴儿。