Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095-1737, USA.
Cell Res. 2012 May;22(5):789-90. doi: 10.1038/cr.2012.49. Epub 2012 Mar 27.
Histone modifications have previously been leveraged to map the locations of candidate enhancer and promoters in one dimensional genomic space. Chepelev . report the first Chromatin Interaction Analysis with Paired-End Tag (ChIA-PET) sequencing of a specific histone modification to systematically map long-range physical interactions among enhancer and promoters, yielding insights into the nature of these interactions.
先前已经利用组蛋白修饰来在一维基因组空间中绘制候选增强子和启动子的位置。Chepelev 等人报告了首个特定组蛋白修饰的染色质互作分析与 Paired-End Tag 测序（ChIA-PET 测序），以系统地绘制增强子和启动子之间的长程物理相互作用，深入了解这些相互作用的本质。
