Deng Zilin, Yang Xiaoquan, Gong Hui, Luo Qingming
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong, University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China.
Opt Express. 2012 Mar 26;20(7):7555-63. doi: 10.1364/OE.20.007555.
To improve the lateral resolution of the blood vessels along arbitrary direction out of focus in photoacoustic microscopy (PAM), we propose an adaptive synthetic-aperture focusing technique (ASAFT) for microvasculature imaging which can be automatically applied to each branch of blood vessels, based on our previous two-dimensional (2D) SAFT. The ASAFT is validated both in the phantom study and in vivo imaging. The results demonstrate that ASAFT can provide images of blood vessels with better lateral resolution both at different depths and along various directions compared with one-dimensional and 2D SAFT.
为了提高光声显微镜（PAM）中非聚焦状态下沿任意方向的血管横向分辨率，基于我们之前的二维（2D）合成孔径聚焦技术（SAFT），我们提出了一种适用于微血管成像的自适应合成孔径聚焦技术（ASAFT），该技术可自动应用于血管的每个分支。ASAFT在体模研究和活体成像中均得到了验证。结果表明，与一维和二维SAFT相比，ASAFT在不同深度和沿不同方向都能提供具有更好横向分辨率的血管图像。
