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本文引用的文献

1
Dynamic and high-resolution metabolic imaging of hyperpolarized [1-13C]-pyruvate in the rat brain using a high-performance gradient insert.利用高性能梯度插入物对大鼠脑内高极化 [1-13C]-丙酮酸进行动态和高分辨率代谢成像。
Magn Reson Med. 2011 May;65(5):1228-33. doi: 10.1002/mrm.22707. Epub 2010 Nov 30.
2
Cardiovascular Applications of Hyperpolarized MRI.超极化磁共振成像的心血管应用
Curr Cardiovasc Imaging Rep. 2011 Apr;4(2):108-115. doi: 10.1007/s12410-011-9066-8. Epub 2011 Jan 19.
3
Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.通过成像技术分析癌症代谢：向临床研究转化的前景。
Neoplasia. 2011 Feb;13(2):81-97. doi: 10.1593/neo.101102.
4
Lactate levels in the brain are elevated upon exposure to volatile anesthetics: a microdialysis study.在接触挥发性麻醉剂后，大脑中的乳酸水平升高：一项微透析研究。
Neurochem Int. 2010 Dec;57(8):940-7. doi: 10.1016/j.neuint.2010.09.014. Epub 2010 Oct 7.
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Increase of signal-to-noise of more than 10,000 times in liquid state NMR.液态核磁共振中信号噪声比提高超过10000倍。
Discov Med. 2003 Dec;3(19):37-9.
6
In vivo 13C spectroscopy in the rat brain using hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate.利用 13C 高极化 [1-(13)C]丙酮酸和 [2-(13)C]丙酮酸进行大鼠脑的体内 13C 波谱分析。
J Magn Reson. 2010 Oct;206(2):210-8. doi: 10.1016/j.jmr.2010.07.006. Epub 2010 Jul 16.
7
Cerebral dynamics and metabolism of hyperpolarized [1-(13)C]pyruvate using time-resolved MR spectroscopic imaging.使用时间分辨磁共振波谱成像研究[1-(13)C]丙酮酸的脑动力学和代谢。
J Cereb Blood Flow Metab. 2010 Oct;30(10):1734-41. doi: 10.1038/jcbfm.2010.93. Epub 2010 Jun 30.
8
Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons.丙酮酸脱氢酶的磷酸化状态可区分培养的大鼠脑星形胶质细胞和神经元的代谢表型。
Glia. 2010 Aug;58(10):1168-76. doi: 10.1002/glia.20996.
9
Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate.在麻醉大鼠脑内使用 1-13C 标记的丙酮酸和 1-13C 乙基丙酮酸进行代谢成像。
Magn Reson Med. 2010 May;63(5):1137-43. doi: 10.1002/mrm.22364.
10
Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.利用 13C 标记的支链氨基酸代谢物对肿瘤进行影像学研究。
Int J Cancer. 2010 Aug 1;127(3):729-36. doi: 10.1002/ijc.25072.

应用 13C 磁共振波谱成像对脑 2-酮异己酸代谢进行成像。

Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized (13)C magnetic resonance spectroscopic imaging.

机构信息

Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark.

出版信息

J Cereb Blood Flow Metab. 2012 Aug;32(8):1508-14. doi: 10.1038/jcbfm.2012.34. Epub 2012 Mar 28.

DOI:10.1038/jcbfm.2012.34
PMID:22453630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3421087/
Abstract

The branched chain amino acid transaminase (BCAT) has an important role in nitrogen shuttling and glutamate metabolism in the brain. The purpose of this study was to describe the cerebral distribution and metabolism of hyperpolarized 2-keto[1-(13)C]isocaproate (KIC) in the normal rat using magnetic resonance modalities. Hyperpolarized KIC is metabolized to [1-(13)C]leucine (leucine) by BCAT. The results show that KIC and its metabolic product, leucine, are present at imageable quantities 20 seconds after end of KIC administration throughout the brain. Further, significantly higher metabolism was observed in hippocampal regions compared with the muscle tissue. In conclusion, the cerebral metabolism of hyperpolarized KIC is imaged and hyperpolarized KIC may be a promising substrate for evaluation of cerebral BCAT activity in conjunction with neurodegenerative disease.

摘要

支链氨基酸转氨酶 (BCAT) 在大脑中的氮穿梭和谷氨酸代谢中具有重要作用。本研究的目的是使用磁共振技术描述正常大鼠中极化 2-酮[1-(13)C]异己酸 (KIC) 的脑分布和代谢。极化 KIC 被 BCAT 代谢为 [1-(13)C]亮氨酸 (亮氨酸)。结果表明，KIC 及其代谢产物亮氨酸在 KIC 给药结束后 20 秒内可在整个大脑中以可成像的量存在。此外，与肌肉组织相比，在海马区观察到更高的代谢。总之，极化 KIC 的脑代谢可以成像，极化 KIC 可能是一种很有前途的底物，可用于结合神经退行性疾病评估大脑中的 BCAT 活性。