Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Trends Neurosci. 2020 May;43(5):343-354. doi: 10.1016/j.tins.2020.03.006. Epub 2020 Apr 8.
Aberrant metabolism is a key factor in many neurological disorders. The ability to measure such metabolic impairment could lead to improved detection of disease progression, and development and monitoring of new therapeutic approaches. Hyperpolarized C magnetic resonance spectroscopy (MRS) is a developing imaging technique that enables non-invasive measurement of enzymatic activity in real time in living organisms. Primarily applied in the fields of cancer and cardiac disease so far, this metabolic imaging method has recently been used to investigate neurological disorders. In this review, we summarize the preclinical research developments in this emerging field, and discuss future prospects for this exciting technology, which has the potential to change the clinical paradigm for patients with neurological disorders.
代谢异常是许多神经疾病的关键因素。能够测量这种代谢损伤可能会导致疾病进展的检测得到改善，并促进新治疗方法的开发和监测。极化 C 磁共振波谱（MRS）是一种不断发展的成像技术，可实时非侵入性地测量活体生物中的酶活性。迄今为止，该代谢成像方法主要应用于癌症和心脏病领域，最近已用于研究神经疾病。在这篇综述中，我们总结了这一新兴领域的临床前研究进展，并讨论了这项令人兴奋的技术的未来前景，它有可能改变神经疾病患者的临床模式。
