通过钙与缝隙连接通道的相互作用调节细胞间钙信号传递。

Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels.

机构信息

Departamento de Neurología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 391, 8330024, Santiago, Chile.

出版信息

Adv Exp Med Biol. 2012;740:777-94. doi: 10.1007/978-94-007-2888-2_34.

DOI:10.1007/978-94-007-2888-2_34

PMID:22453969

Abstract

The synchronization of numerous cellular events requires complex electric and metabolic cell-cell interactions. Connexins are a family of membrane proteins that constitute the molecular basis of two kinds of channels: gap junction channels (GJCs), which allow direct cytoplasm-cytoplasm communication, and hemichannels (HCs) that provide a pathway for exchanges between the intra and extra-cellular milieu. Both kind of connexin-based channels support intercellular communication via intercellular propagation of calcium waves. Here, we review evidence supporting the role of Ca(2+) in the regulation of GJCs and HCs formed by connexins. Also it is speculated how these connexin-based channels could contribute to the propagation of intercellular Ca(2+) signals.

摘要

众多细胞事件的同步需要复杂的电和代谢细胞-细胞相互作用。连接蛋白是一类膜蛋白，构成了两种通道的分子基础：间隙连接通道（GJCs），允许直接细胞质-细胞质通讯，和半通道（HCs），提供细胞内外环境之间交换的途径。这两种连接蛋白通道都通过细胞内钙离子波的传播支持细胞间通讯。在这里，我们回顾了支持钙（Ca(2+)）在调节由连接蛋白形成的 GJCs 和 HCs 中的作用的证据。此外，还推测了这些基于连接蛋白的通道如何有助于细胞间 Ca(2+)信号的传播。