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Association of FTO polymorphisms with early age of obesity in obese Italian subjects.FTO基因多态性与意大利肥胖受试者肥胖起始年龄较早的关联。
Exp Diabetes Res. 2012;2012:872176. doi: 10.1155/2012/872176. Epub 2012 Feb 20.
2
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.全基因组关联扫描显示，FTO基因中的遗传变异与肥胖相关性状有关。
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3
[Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population].[FTO和MC4R基因多态性变体与鞑靼人群肥胖的关联]
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4
The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population.FTO 基因变异与阿联酋人群的饮食摄入和体重指数有关。
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Fat-mass and obesity-associated gene polymorphisms and weight gain after risperidone treatment in first episode schizophrenia.首发精神分裂症患者使用利培酮治疗后脂肪量与肥胖相关基因多态性及体重增加情况
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Association between rs9930506 polymorphism of the fat mass & obesity-associated (FTO) gene & onset of obesity in Polish adults.波兰成年人中脂肪量与肥胖相关（FTO）基因的rs9930506多态性与肥胖发病之间的关联。
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Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.LEPR、FTO、MC4R 和 PPARG-2 多态性与学龄儿童肥胖特征和代谢表型的关联。
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8
'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.“肥胖相关”基因（FTO）：在德国肥胖儿童和青少年的生活方式干预中，变异体rs9939609与体重减轻及脂质代谢标志物无显著关联。
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Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C-reactive protein levels in multi-ethnic Malaysian adults.马来西亚多民族成年人中 FTO rs9930506 对肥胖的影响以及基因变异与膳食蛋白质和维生素 E 对 C-反应蛋白水平的相互作用。
J Hum Nutr Diet. 2018 Dec;31(6):758-772. doi: 10.1111/jhn.12593. Epub 2018 Aug 23.
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Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS.根据多囊卵巢综合征患者的肥胖情况，FTO 基因变异和单倍型与多囊卵巢综合征易感性的关联存在差异。
Reprod Sci. 2023 Jul;30(7):2166-2176. doi: 10.1007/s43032-022-01149-w. Epub 2023 Jan 5.

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Genetic association of gene polymorphisms with obesity and its related phenotypes: A case-control study.基因多态性与肥胖及其相关表型的遗传关联：一项病例对照研究。
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Interaction Effects of and Polymorphisms on Total Body Weight Loss, Post-Surgery Weight, and Post-Body Mass Index after Bariatric Surgery.肥胖症手术后，[具体基因]多态性与[另一基因]多态性对总体重减轻、术后体重及术后体重指数的交互作用。
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Initial Weight Loss, Anthropometric Parameters, and Proinflammatory Transcript Levels in Patients with Class I Obesity.I 类肥胖患者的初始体重减轻、人体测量参数和促炎转录水平
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Food Technol Biotechnol. 2023 Mar;61(1):14-26. doi: 10.17113/ftb.61.01.23.7594.
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Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS.根据多囊卵巢综合征患者的肥胖情况，FTO 基因变异和单倍型与多囊卵巢综合征易感性的关联存在差异。
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Common Obesity SNPs Interact with Actionable Environmental Factors: Physical Activity, Sugar-Sweetened Beverages and Wine Consumption.常见肥胖相关单核苷酸多态性与可干预的环境因素相互作用：体力活动、含糖饮料和饮酒。
Nutrients. 2022 Oct 9;14(19):4202. doi: 10.3390/nu14194202.
7
Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer.揭示肥胖相关基因（FTO）、生活方式与癌症之间复杂的相互作用。
Adv Nutr. 2022 Dec 22;13(6):2406-2419. doi: 10.1093/advances/nmac101.
8
Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study.营养遗传学变异与肥胖患者饮食/生活方式干预反应：一项初步研究。
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Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population.FTO和MC4R基因多态性在印度人群肥胖加剧中的作用及其与2型糖尿病风险的间接关联
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Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population.脂肪量与肥胖相关（FTO）基因的遗传变异赋予巴西人群极端肥胖风险并调节肥胖程度。
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本文引用的文献

1
Linkage disequilibrium in finite populations.有限群体中的连锁不平衡。
Theor Appl Genet. 1968 Jun;38(6):226-31. doi: 10.1007/BF01245622.
2
FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies.FTO、2 型糖尿病与成年后体重增加：来自斯堪的纳维亚 HUNT、MDC 和 MPP 研究的 41504 例受试者的荟萃分析。
Diabetes. 2011 May;60(5):1637-44. doi: 10.2337/db10-1340. Epub 2011 Mar 11.
3
From GWAS to biology: lessons from FTO.从 GWAS 到生物学：FTO 的启示。
Ann N Y Acad Sci. 2011 Mar;1220:162-71. doi: 10.1111/j.1749-6632.2010.05903.x.
4
The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China.中国北京儿童和青少年中，肥胖相关基因的常见 rs9939609 变异与肥胖风险相关。
BMC Med Genet. 2010 Jul 5;11:107. doi: 10.1186/1471-2350-11-107.
5
Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia.克罗埃西亚亚得里亚海东部岛屿人群中 FTO 基因常见单核苷酸多态性与肥胖相关人体测量特征相关联。
PLoS One. 2010 Apr 28;5(4):e10375. doi: 10.1371/journal.pone.0010375.
6
Life course variations in the associations between FTO and MC4R gene variants and body size.FTO 和 MC4R 基因变异与体型之间关联的生命历程变化。
Hum Mol Genet. 2010 Feb 1;19(3):545-52. doi: 10.1093/hmg/ddp504. Epub 2009 Oct 31.
7
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.黑皮质素4受体（MC4R）和脂肪量和肥胖相关基因（FTO）常见基因变异对欧洲普通人群肥胖的联合影响。
J Mol Med (Berl). 2009 May;87(5):537-46. doi: 10.1007/s00109-009-0451-6. Epub 2009 Mar 3.
8
Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions.人类肥胖症：一种对环境条件高度敏感的遗传性神经行为障碍。
Diabetes. 2008 Nov;57(11):2905-10. doi: 10.2337/db08-0210.
9
FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.FTO基因变异与新加坡华族和马来族人群的肥胖有关。
Diabetes. 2008 Oct;57(10):2851-7. doi: 10.2337/db08-0214. Epub 2008 Jul 3.
10
Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.脂肪量和肥胖相关（FTO）基因的常见变异会增加中国人群患肥胖症的风险并调节体重指数。
Diabetes. 2008 Aug;57(8):2245-52. doi: 10.2337/db08-0377. Epub 2008 May 16.

FTO基因多态性与意大利肥胖受试者肥胖起始年龄较早的关联。

Association of FTO polymorphisms with early age of obesity in obese Italian subjects.

作者信息

Sentinelli Federica, Incani Michela, Coccia Federica, Capoccia Danila, Cambuli Valentina Maria, Romeo Stefano, Cossu Efisio, Cavallo Maria Gisella, Leonetti Frida, Baroni Marco Giorgio

机构信息

Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Policlinico Universitario, 09042 Cagliari, Italy.

出版信息

Exp Diabetes Res. 2012;2012:872176. doi: 10.1155/2012/872176. Epub 2012 Feb 20.

DOI:10.1155/2012/872176
PMID:22454631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3290805/
Abstract

Obesity is recognized as a major health problem worldwide. Genetic factors play a major role in obesity, and genomewide association studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population. Aims of our study are to investigate: (1) the association of FTO gene SNPs rs9939609 and rs9930506 with body mass index (BMI) and obesity-related parameters in a large cohort (n = 752) of Italian obese subjects; (2) the association between the two FTO SNPs and age of onset of obesity. Our results demonstrate a strong association between FTO SNPs rs9939609 (P < 0.043) and rs9930506 (P < 0.029) with BMI in the Italian population. FTO rs9930506 was significantly associated with higher BMI in a G allele dose-dependent manner (BMI + 1.4 kg/m² per G allele). We also observed that the association with BMI of the two FTO variants varied with age, with the carriers of the risk alleles developing an increase in body weight earlier in life. In conclusion, our study further demonstrates a role of the genetic variability in FTO on BMI in a large Italian population.

摘要

肥胖被公认为是全球主要的健康问题。遗传因素在肥胖中起主要作用，全基因组关联研究已提供证据表明，脂肪量和肥胖相关（FTO）基因内的几个常见变异与肥胖显著相关。关于意大利人群中FTO的现有数据非常有限。我们研究的目的是调查：（1）FTO基因单核苷酸多态性rs9939609和rs9930506与一大群（n = 752）意大利肥胖受试者的体重指数（BMI）及肥胖相关参数之间的关联；（2）这两个FTO单核苷酸多态性与肥胖发病年龄之间的关联。我们的结果表明，在意大利人群中，FTO单核苷酸多态性rs9939609（P < 0.043）和rs9930506（P < 0.029）与BMI之间存在强关联。FTO rs9930506以G等位基因剂量依赖性方式与较高的BMI显著相关（每G等位基因BMI增加1.4 kg/m²）。我们还观察到，这两个FTO变异与BMI的关联随年龄而变化，风险等位基因携带者在生命早期体重增加。总之，我们的研究进一步证明了FTO基因变异性在一大群意大利人群中对BMI的作用。