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肥胖代谢途径与表观遗传影响交叉点处的基因多态性

Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences.

作者信息

Popović Ana-Marija, Huđek Turković Ana, Žuna Kristina, Bačun-Družina Višnja, Rubelj Ivica, Matovinović Martina

机构信息

General Hospital Gospić, Kaniška 111, 53000 Gospić, Croatia.

Faculty of Food Technology and Biotechnology University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia.

出版信息

Food Technol Biotechnol. 2023 Mar;61(1):14-26. doi: 10.17113/ftb.61.01.23.7594.

DOI:10.17113/ftb.61.01.23.7594
PMID:37200795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10187569/
Abstract

In this review, we summarize the current state of knowledge on the fat mass and obesity-associated () gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigenetic influence on the gene as a new approach in the treatment and management of obesity. Several known substances have a positive effect on reducing expression. Depending on which variant of the single nucleotide polymorphism (SNP) is present, the profile and level of gene expression changes. Implementation of environmental change measures could lead to reduced phenotypic manifestation of expression. Treating obesity through gene regulation will have to include various complex signal pathways in which takes part. Identification of gene polymorphisms may be useful for the development of individual obesity management strategies, including the recommendation of taking certain foods and supplements.

摘要

在本综述中，我们总结了目前关于脂肪量和肥胖相关（FTO）基因的知识现状及其在肥胖中的作用。FTO编码的蛋白质参与了导致肥胖以及其他代谢复杂性的多种分子途径。本综述强调了表观遗传对FTO基因的影响，将其作为肥胖治疗和管理的一种新方法。几种已知物质对降低FTO表达有积极作用。根据单核苷酸多态性（SNP）存在的变体不同，基因表达的谱和水平会发生变化。实施环境改变措施可能会导致FTO表达的表型表现降低。通过FTO基因调控治疗肥胖将不得不包括FTO参与的各种复杂信号通路。鉴定FTO基因多态性可能有助于制定个性化的肥胖管理策略，包括推荐食用某些食物和补充剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/10bb64dc1cb6/FTB-61-14-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/de379faad9f8/FTB-61-14-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/e96485d14853/FTB-61-14-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/542225747313/FTB-61-14-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/b68fe75ba88f/FTB-61-14-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/10bb64dc1cb6/FTB-61-14-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/de379faad9f8/FTB-61-14-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/e96485d14853/FTB-61-14-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/542225747313/FTB-61-14-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/b68fe75ba88f/FTB-61-14-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7db/10187569/10bb64dc1cb6/FTB-61-14-f5.jpg

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Clin Nutr ESPEN. 2021 Apr;42:221-226. doi: 10.1016/j.clnesp.2021.01.034. Epub 2021 Feb 13.
2
Fat mass and obesity-associated (FTO) gene epigenetic modifications in gestational diabetes: new insights and possible pathophysiological connections.妊娠期糖尿病中脂肪量和肥胖相关（FTO）基因的表观遗传修饰：新的见解和可能的病理生理联系。
Acta Diabetol. 2021 Aug;58(8):997-1007. doi: 10.1007/s00592-020-01668-5. Epub 2021 Mar 20.
3
MedComm (2020). 2025 Mar 10;6(3):e70134. doi: 10.1002/mco2.70134. eCollection 2025 Mar.
4
Association of FTO variants rs9939609 and rs1421085 with elevated sugar and fat consumption in adult obesity.FTO 基因变异 rs9939609 和 rs1421085 与成年人肥胖中糖和脂肪摄入增加的关联。
Sci Rep. 2024 Oct 27;14(1):25618. doi: 10.1038/s41598-024-77004-6.
5
Risk of Fat Mass- and Obesity-Associated Gene-Dependent Obesogenic Programming by Formula Feeding Compared to Breastfeeding.配方奶喂养相较于母乳喂养与脂肪量和肥胖相关基因依赖性致肥胖性编程的风险。
Nutrients. 2024 Jul 28;16(15):2451. doi: 10.3390/nu16152451.
6
Sarcopenia as a Risk Factor for Alzheimer's Disease: Genetic and Epigenetic Perspectives.肌少症作为阿尔茨海默病的风险因素：遗传和表观遗传观点。
Genes (Basel). 2024 Apr 27;15(5):561. doi: 10.3390/genes15050561.
7
The effects of FTO gene rs9939609 polymorphism on the association between colorectal cancer and dietary intake.FTO基因rs9939609多态性对结直肠癌与饮食摄入之间关联的影响。
Front Nutr. 2023 Jul 20;10:1215559. doi: 10.3389/fnut.2023.1215559. eCollection 2023.
No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males.
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4
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8
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