Centre for Theumatic Diseases and University Department of Medicine, Royal Infirmary, Glasgow.
Br J Clin Pharmacol. 1974 Aug;1(4):287-90. doi: 10.1111/j.1365-2125.1974.tb00254.x.
1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation. 3 The use of probenecid with indomethacin at night may be useful in reducing morning stiffness and pain. 4 Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.
在三组类风湿关节炎患者中，研究了丙磺舒添加到吲哚美辛口服和直肠给药方案中的效果。
丙磺舒的添加增加了口服和直肠给予的吲哚美辛的血浆水平，并显著降低了关节炎症的临床参数。
吲哚美辛与丙磺舒在夜间联合使用可能有助于减少晨僵和疼痛。
尽管在同时使用丙磺舒治疗期间吲哚美辛的血浆水平显著升高，但观察到的不良反应很少。
