吲哚美辛-丙磺舒相互作用的临床意义。
The clinical significance of indomethacin-probenecid interaction.
机构信息
Centre for Theumatic Diseases and University Department of Medicine, Royal Infirmary, Glasgow.
出版信息
Br J Clin Pharmacol. 1974 Aug;1(4):287-90. doi: 10.1111/j.1365-2125.1974.tb00254.x.
Abstract
1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation. 3 The use of probenecid with indomethacin at night may be useful in reducing morning stiffness and pain. 4 Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.
摘要
在三组类风湿关节炎患者中，研究了丙磺舒添加到吲哚美辛口服和直肠给药方案中的效果。
丙磺舒的添加增加了口服和直肠给予的吲哚美辛的血浆水平，并显著降低了关节炎症的临床参数。
吲哚美辛与丙磺舒在夜间联合使用可能有助于减少晨僵和疼痛。
尽管在同时使用丙磺舒治疗期间吲哚美辛的血浆水平显著升高，但观察到的不良反应很少。
相似文献
1
The clinical significance of indomethacin-probenecid interaction.吲哚美辛-丙磺舒相互作用的临床意义。
Br J Clin Pharmacol. 1974 Aug;1(4):287-90. doi: 10.1111/j.1365-2125.1974.tb00254.x.
2
An observer-blind crossover study to compare the efficacies of flurbiprofen, indomethacin and naproxen given orally and rectally in the relief of night pain and morning stiffness due to rheumatoid arthritis.一项观察者盲法交叉研究，比较口服和直肠给药氟比洛芬、吲哚美辛和萘普生缓解类风湿性关节炎所致夜间疼痛和晨僵的疗效。
J Int Med Res. 1988 May-Jun;16(3):189-96. doi: 10.1177/030006058801600304.
3
The interaction between indomethacin and probenecid. A clinical and pharmacokinetic study.吲哚美辛与丙磺舒的相互作用：一项临床与药代动力学研究
Clin Pharmacol Ther. 1978 Sep;24(3):298-307. doi: 10.1002/cpt1978243298.
4
Interaction of indomethacin and acetylsalicylic acid as shown by the serum concentrations of indomethacin and salicylate.吲哚美辛和乙酰水杨酸的相互作用，通过吲哚美辛和水杨酸盐的血清浓度来体现。
Eur J Clin Pharmacol. 1975 Dec 19;9(2-3):199-207. doi: 10.1007/BF00614018.
5
The effects of probenecid upon the individual components of indomethacin elimination.丙磺舒对吲哚美辛消除各组分的影响。
J Pharmacol Exp Ther. 1977 May;201(2):463-70.
6
Clinical Pharmacokinetics of indomethacin.吲哚美辛的临床药代动力学
Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58. doi: 10.2165/00003088-198106040-00001.
7
Probenecid inhibits the glucuronidation of indomethacin and O-desmethylindomethacin in humans. A pilot experiment.丙磺舒可抑制人体中吲哚美辛和O-去甲基吲哚美辛的葡萄糖醛酸化。一项初步实验。
Pharm World Sci. 1994 Feb 18;16(1):22-6. doi: 10.1007/BF01870935.
8
A double-blind comparison of oral ketoprofen 'controlled release' and indomethacin suppository in the treatment of rheumatoid arthritis with special regard to morning stiffness and pain on awakening.口服酮洛芬“控释剂”与吲哚美辛栓剂治疗类风湿性关节炎的双盲比较，特别关注晨僵和觉醒时疼痛。
Curr Med Res Opin. 1993;13(3):127-32. doi: 10.1185/03007999309111541.
9
The effects of differing pharmaceutical preparations of indomethacin on night pain and morning stiffness in patients with rheumatoid arthritis.吲哚美辛不同药物制剂对类风湿性关节炎患者夜间疼痛和晨僵的影响。
Curr Med Res Opin. 1987;10(9):592-5. doi: 10.1185/03007998709112412.
10
The effect of frusemide on indomethacin plasma levels.呋塞米对吲哚美辛血药浓度的影响。
Br J Clin Pharmacol. 1974 Dec;1(6):485-9. doi: 10.1111/j.1365-2125.1974.tb01698.x.
引用本文的文献
1
Adverse drug interactions with nonsteroidal anti-inflammatory drugs (NSAIDs). Recognition, management and avoidance.非甾体抗炎药（NSAIDs）的药物不良相互作用。识别、管理与避免。
Drug Saf. 1993 Feb;8(2):99-127. doi: 10.2165/00002018-199308020-00002.
2
Clinical Pharmacokinetics of indomethacin.吲哚美辛的临床药代动力学
Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58. doi: 10.2165/00003088-198106040-00001.
3
Clinical pharmacokinetics of non-steroidal anti-inflammatory drugs.非甾体抗炎药的临床药代动力学
Clin Pharmacokinet. 1983 Jul-Aug;8(4):297-331. doi: 10.2165/00003088-198308040-00003.
4
Correlation plasma levels, NSAID and therapeutic response.
Clin Rheumatol. 1985 Jun;4(2):124-32. doi: 10.1007/BF02032282.
5
The problems and pitfalls of NSAID therapy in the elderly (Part II).老年人非甾体抗炎药治疗的问题与陷阱（第二部分）
Drugs Aging. 1991 May;1(3):212-27. doi: 10.2165/00002512-199101030-00005.
6
Drug interactions and clinical pharmacokinetics.药物相互作用与临床药代动力学。
Clin Pharmacokinet. 1976;1(5):351-72. doi: 10.2165/00003088-197601050-00003.
7
The comparative gastric ulcerogenic activities of non-steroid anti-inflammatory drugs.非甾体抗炎药的相对致胃溃疡活性。
Agents Actions. 1977 Dec;7(5-6):573-7. doi: 10.1007/BF02111132.
本文引用的文献
1
208.--INDOMETHACIN IN THE TREATMENT OF ACUTE GOUT.208.——消炎痛治疗急性痛风
Practitioner. 1965 Apr;194:560-5.
2
THE METABOLITES OF INDOMETHACIN, A NEW ANTI-INFLAMMATORY DRUG.
J Pharmacol Exp Ther. 1964 Feb;143:215-20.
3
DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.类风湿关节炎的诊断标准：美国风湿病协会委员会1958年修订版。
Ann Rheum Dis. 1959 Mar;18(1):49-51; French transl 51-2; Spanish transl 52-3.
4
The renal excretion of indomethacin and its inhibition by probenecid.
Clin Pharmacol Ther. 1968 Jan-Feb;9(1):89-93. doi: 10.1002/cpt19689189.
5
6
Editorial: Pharmacokinetics--master or servant?社论：药代动力学——主还是仆？
Eur J Clin Pharmacol. 1973 Jun;6(1):1-2. doi: 10.1007/BF00561792.
7
Simultaneous pharmacokinetics of indomethacin in serum and synovial fluid.吲哚美辛在血清和滑液中的同步药代动力学。
Ann Rheum Dis. 1973 Sep;32(5):433-5. doi: 10.1136/ard.32.5.433.
8
An assessment of grip strength measurement in rheumatoid arthritis.类风湿关节炎握力测量的评估
Scand J Rheumatol. 1974;3(1):17-23. doi: 10.3109/03009747409165124.
9
Method for assessing therapeutic potential of anti-inflammatory antirheumatic drugs in rheumatoid arthritis.评估抗炎抗风湿药物对类风湿关节炎治疗潜力的方法。
Br Med J. 1973 Jun 23;2(5868):685-8. doi: 10.1136/bmj.2.5868.685.
10
The metabolism of indomethacin in man.吲哚美辛在人体中的代谢。
J Pharmacol Exp Ther. 1972 Jun;181(3):563-75.
Zotero 插件