普萘洛尔和地西泮对躯体性焦虑和精神性焦虑的反应
Response to propranolol and diazepam in somatic and psychic anxiety.
作者信息
Tyrer P J, Lader M H
出版信息
Br Med J. 1974 Apr 6;2(5909):14-6. doi: 10.1136/bmj.2.5909.14.
Abstract
A total of 12 chronically anxious psychiatric outpatients were treated with racemic propranolol (Inderal), diazepam (Valium), and placebo for one week each, using a balanced cross-over experimental design. Six patients had predominantly somatic anxiety, complaining mostly of bodily symptoms, and six had mainly psychic anxiety, complaining primarily of psychological symptoms. Clinical ratings of anxiety were made by patient and psychiatrist after each treatment. Though diazepam was in general more effective than propranolol or placebo in relieving anxiety, propranolol was more effective than placebo in patients with somatic anxiety but not in those with psychic anxiety. We suggest that propranolol should be reserved for patients whose anxiety symptoms are mainly somatic.
摘要
采用平衡交叉实验设计，对12名慢性焦虑症精神科门诊患者分别使用消旋普萘洛尔（心得安）、地西泮（安定）和安慰剂进行为期一周的治疗。6名患者主要表现为躯体焦虑，主要抱怨身体症状；6名患者主要表现为精神焦虑，主要抱怨心理症状。每次治疗后，由患者和精神科医生对焦虑进行临床评分。虽然总体上，地西泮在缓解焦虑方面比普萘洛尔或安慰剂更有效，但普萘洛尔对躯体焦虑患者比安慰剂更有效，而对精神焦虑患者则不然。我们建议，普萘洛尔应仅用于焦虑症状主要为躯体性的患者。
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