泼尼松治疗对静脉用氢化可的松半衰期的影响。
The effect of prednisone treatment on the half-life of intravenous hydrocortisone.
机构信息
Asthma Research Concil Clinical Pharmacology Unit, Departmet of Medicine, Cardiothoracic Institute, Fulham Road, London.
出版信息
Br J Clin Pharmacol. 1974 Jun;1(3):237-40. doi: 10.1111/j.1365-2125.1974.tb00243.x.
Abstract
1 The half-life of hydrocortisone (cortisol) has been measured in six patients before and after a three-week course of prednisone given for asthma. 2 There was considerable variation in peak plasma level of cortisol both within and between patients, but on both occasions the plasma half-lives were the same. 3 It was concluded that short courses of prednisone have no effect on the handling of hydrocortisone.
摘要
在 6 名因哮喘接受 3 周泼尼松治疗的患者中，测量了氢化可的松（皮质醇）的半衰期。
皮质醇的血浆峰浓度在患者内和患者间均有很大差异，但两次的血浆半衰期均相同。
结论是，短期泼尼松治疗对氢化可的松的处理没有影响。
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