Yaduvanshi B, Mathur Rajani, Mathur S R, Velpandian T
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110, India.
Indian J Pharm Sci. 2011 May;73(3):303-6. doi: 10.4103/0250-474X.93523.
Tridax procumbens L. (Compositae) is a common weed that grows in the rice fields of India. Traditionally the juice from leaves of Tridax procumbens has been used for healing dermal wound. However, in experimental studies, equivocal pro and anti-healing action of T. procumbens has been demonstrated. The present study evaluates the effect of topical ointment formulation of the leaf juice of T. procumbens using excision wound model in mice. Excision wounds (4 mm, i.d.) were inflicted on depilated back of mice. Ointment formulation of TP (50 mg of either 1 or 4 mg/g) was applied twice daily for 4 days on the dermal wound. Similarly, control group was treated with VEGF ointment (50 mg of 1 μg/g). The parameters observed were re-epithelization, vascularity, fibroblast number, collagen content. The healing exerted by TP (1 mg/g) was comparable to VEGF (1 μg/g). On the other hand, TP (4 mg/g) induced inflammation, edematous tissue and decreased vascularity. Taken together, the results imply that TP possesses dose dependent pro-healing potential, and its high dose exerts inflammatory reaction.
三叶鬼针草（菊科）是一种常见杂草，生长于印度的稻田中。传统上，三叶鬼针草叶子的汁液被用于治疗皮肤伤口。然而，在实验研究中，已证实三叶鬼针草具有矛盾的促进和抑制愈合作用。本研究使用小鼠切除伤口模型评估了三叶鬼针草叶汁局部软膏制剂的效果。在脱毛的小鼠背部造成切除伤口（内径4毫米）。将TP软膏制剂（50毫克，浓度为1或4毫克/克）每天两次涂抹于皮肤伤口上，持续4天。同样，对照组用VEGF软膏（50毫克，浓度为1微克/克）治疗。观察的参数包括再上皮化、血管形成、成纤维细胞数量、胶原蛋白含量。TP（1毫克/克）产生的愈合效果与VEGF（1微克/克）相当。另一方面，TP（4毫克/克）引发炎症、组织水肿并减少血管形成。综上所述，结果表明TP具有剂量依赖性的促进愈合潜力，其高剂量会引发炎症反应。
