Barua C C, Talukdar A, Begum S A, Sarma D K, Fathak D C, Barua A G, Bora R S
Department of Pharmacology and Toxicology, College of Veterinary Science, Assam Agricultural University, Khanapara, Guwahati 781 022, India.
Indian J Exp Biol. 2009 Dec;47(12):1001-5.
Wound healing activity of methanolic extract of leaves of Alternanthera brasiliana Kuntz was studied by excision and incision wound model (in vivo) in Sprague Dawley rats and by Chorioallantoic membrane (CAM) model (In vitro) in 9-day-old embryonated chicken eggs. In excision wound model, compared to the control group, per cent contraction of wound was significantly higher in A. brasiliana (5% w/w ointment) treated group. In incision wound model, tensile strength of the healing tissue after treatment with A. brasiliana was found to be significantly higher compared to the control group indicating better wound healing activity of the test plant. These findings were also confirmed by histopathological examination. The extract also promoted angiogenesis as evidenced by CAM model. The results suggested that methanolic extract of A. brasiliana possess significant wound healing potential in normal wound.
采用切除和切开伤口模型（体内实验），以斯普拉格-道利大鼠为实验对象，同时采用鸡胚绒毛尿囊膜（CAM）模型（体外实验），以9日龄的鸡胚为实验对象，研究了巴西节节草叶片甲醇提取物的伤口愈合活性。在切除伤口模型中，与对照组相比，巴西节节草（5% w/w软膏）治疗组伤口的收缩百分比显著更高。在切开伤口模型中，发现用巴西节节草治疗后愈合组织的抗张强度与对照组相比显著更高，表明受试植物具有更好的伤口愈合活性。这些结果也通过组织病理学检查得到了证实。CAM模型证明该提取物还能促进血管生成。结果表明，巴西节节草甲醇提取物在正常伤口愈合方面具有显著的潜力。
