• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阐明 5-HT(1A) 和 5-HT(7) 受体在 8-OH-DPAT 诱导实验性创伤性脑损伤后行为恢复中的作用。

Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury.

机构信息

Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15260, USA.

出版信息

Neurosci Lett. 2012 May 2;515(2):153-6. doi: 10.1016/j.neulet.2012.03.033. Epub 2012 Mar 21.

DOI:10.1016/j.neulet.2012.03.033
PMID:22465320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3328631/
Abstract

8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). This study is a first attempt to decipher whether the benefits induced by 8-OH-DPAT after TBI are mediated by 5-HT(1A) or 5-HT(7) receptors. A single i.p. injection of 8-OH-DPAT (0.5 mg/kg) alone or co-administered with either the 5-HT(1A) or 5-HT(7) receptor antagonists WAY 100635 (0.5 mg/kg) or SB 269970 HCl (2.0 mg/kg), respectively, or vehicle control (1.0 mL/kg) was given 15 min after cortical impact or sham injury. Function was assessed by established motor and cognitive tests. No difference in motor performance was observed among the TBI groups. Spatial acquisition was enhanced, relative to vehicle controls, by 8-OH-DPAT alone and when co-administered with WAY 100635, but not when combined with SB 269970 HCl. These data imply that 5-HT(1A) receptor antagonism does not abate the 8-OH-DPAT-induced cognitive benefits, but 5-HT(7) receptor antagonism does, which suggests that the 8-OH-DPAT-induced benefits in this single administration paradigm may be mediated more by 5-HT(7) versus 5-HT(1A) receptors. Evaluation of a specific 5-HT(7) receptor agonist will further elucidate the contribution of 5-HT(1A) and 5-HT(7) receptors on behavioral recovery conferred by acute 8-OH-DPAT treatment after TBI.

摘要

8-OH-DPAT 是一种 5-HT(1A/7) 受体激动剂，可增强创伤性脑损伤 (TBI) 后的行为恢复。本研究首次尝试解析 8-OH-DPAT 在 TBI 后诱导的益处是否由 5-HT(1A)或 5-HT(7)受体介导。皮质撞击或假损伤后 15 分钟，单独或分别与 5-HT(1A)或 5-HT(7)受体拮抗剂 WAY 100635（0.5 mg/kg）或 SB 269970 HCl（2.0 mg/kg）共给药，或给予 vehicle 对照（1.0 mL/kg），单次腹腔注射 8-OH-DPAT（0.5 mg/kg）。通过既定的运动和认知测试评估功能。TBI 组之间的运动表现没有差异。与 vehicle 对照相比，8-OH-DPAT 单独给药以及与 WAY 100635 共给药时，空间习得得到增强，但与 SB 269970 HCl 联合给药时则不然。这些数据表明，5-HT(1A)受体拮抗作用不会减弱 8-OH-DPAT 诱导的认知益处，但 5-HT(7)受体拮抗作用会减弱，这表明在单次给药范式中，8-OH-DPAT 诱导的益处可能更多地由 5-HT(7)而不是 5-HT(1A)受体介导。评估特定的 5-HT(7)受体激动剂将进一步阐明 5-HT(1A)和 5-HT(7)受体在急性 8-OH-DPAT 治疗 TBI 后对行为恢复的贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee88/3328631/0d8971216c47/nihms-365845-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee88/3328631/6b9021d6875e/nihms-365845-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee88/3328631/8f84157df4e7/nihms-365845-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee88/3328631/0d8971216c47/nihms-365845-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee88/3328631/6b9021d6875e/nihms-365845-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee88/3328631/8f84157df4e7/nihms-365845-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee88/3328631/0d8971216c47/nihms-365845-f0003.jpg

相似文献

1
Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury.阐明 5-HT(1A) 和 5-HT(7) 受体在 8-OH-DPAT 诱导实验性创伤性脑损伤后行为恢复中的作用。
Neurosci Lett. 2012 May 2;515(2):153-6. doi: 10.1016/j.neulet.2012.03.033. Epub 2012 Mar 21.
2
The therapeutic efficacy conferred by the 5-HT(1A) receptor agonist 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) after experimental traumatic brain injury is not mediated by concomitant hypothermia.5-羟色胺（5-HT）1A 受体激动剂 8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）在实验性创伤性脑损伤后所赋予的治疗效果并非由伴随的体温过低介导。
J Neurotrauma. 2004 Feb;21(2):175-85. doi: 10.1089/089771504322778631.
3
8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents.8-羟基二丙基氨基四氢萘作用于5-羟色胺1A和5-羟色胺7受体，从而在啮齿动物中诱发体温过低。
Eur J Pharmacol. 2004 Mar 8;487(1-3):125-32. doi: 10.1016/j.ejphar.2004.01.031.
4
A delayed and chronic treatment regimen with the 5-HT1A receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning.在皮质撞击损伤后，使用5-羟色胺1A受体激动剂8-羟基二丙胺四乙酸进行延迟和长期治疗方案，有助于运动恢复和空间学习能力的获得。
Behav Brain Res. 2008 Dec 1;194(1):79-85. doi: 10.1016/j.bbr.2008.06.025. Epub 2008 Jul 1.
5
Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma.5-羟色胺（1A）受体激动剂8-羟基二丙胺四乙酸（8-OH-DPAT）的急性治疗和长期环境富集在实验性脑损伤后带来神经行为益处。
Behav Brain Res. 2007 Feb 27;177(2):186-94. doi: 10.1016/j.bbr.2006.11.036. Epub 2006 Dec 12.
6
Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury.实验性创伤性脑损伤后 8-OH-DPAT 与环境富集联合治疗方案的评价。
J Neurotrauma. 2010 Nov;27(11):2021-32. doi: 10.1089/neu.2010.1535. Epub 2010 Oct 28.
7
The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window.脑外伤后单次全身给予8-OH-DPAT所带来的神经行为益处局限于一个狭窄的治疗窗。
Neurosci Lett. 2007 Apr 12;416(2):165-8. doi: 10.1016/j.neulet.2007.02.006. Epub 2007 Feb 7.
8
5-Hydroxytryptamine(1A) receptor-stimulated [(35)S]GTPgammaS binding in rat brain: absence of regional differences in coupling efficiency.5-羟色胺（1A）受体刺激大鼠脑内的[（35）S]GTPγS结合：偶联效率无区域差异。
J Pharmacol Exp Ther. 2000 Feb;292(2):684-91.
9
Delta(9)-tetrahydrocannabinol prolongs the immobility time in the mouse forced swim test: involvement of cannabinoid CB(1) receptor and serotonergic system.Δ⁹-四氢大麻酚延长小鼠强迫游泳试验中的不动时间：大麻素CB₁受体和5-羟色胺能系统的参与
Eur J Pharmacol. 2008 Jul 28;589(1-3):117-21. doi: 10.1016/j.ejphar.2008.03.046. Epub 2008 Apr 8.
10
Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors.5-羟色胺（5-HT）1A 受体失活后，8-羟基二丙胺基四氢萘（8-OH-DPAT）对大鼠被动回避行为的促进作用
Br J Pharmacol. 1999 Dec;128(8):1691-8. doi: 10.1038/sj.bjp.0702974.

引用本文的文献

1
Delayed-and-abbreviated environmental enrichment after traumatic brain injury confers neurobehavioral benefits similar to immediate-and-continuous exposure.创伤性脑损伤后延迟和简短的环境丰富化可带来类似于即时和持续暴露的神经行为益处。
Brain Res. 2025 Jan 1;1846:149281. doi: 10.1016/j.brainres.2024.149281. Epub 2024 Oct 16.
2
Strain in the Midbrain: Impact of Traumatic Brain Injury on the Central Serotonin System.中脑应变：创伤性脑损伤对中枢5-羟色胺系统的影响。
Brain Sci. 2024 Jan 5;14(1):51. doi: 10.3390/brainsci14010051.
3
Altered Serotonin 2A (5-HT) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance.

本文引用的文献

1
Traumatic brain injury-induced cognitive and histological deficits are attenuated by delayed and chronic treatment with the 5-HT1A-receptor agonist buspirone.创伤性脑损伤引起的认知和组织学缺陷可通过延迟和慢性使用 5-HT1A 受体激动剂丁螺环酮得到缓解。
J Neurotrauma. 2012 Jul 1;29(10):1898-907. doi: 10.1089/neu.2012.2358. Epub 2012 Apr 23.
2
On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor.关于脑 5-HT7 受体在体温降低机制中的作用：与通过 5-HT1A 和 5-HT3 受体介导的体温降低的比较。
Neuropharmacology. 2011 Dec;61(8):1360-5. doi: 10.1016/j.neuropharm.2011.08.022. Epub 2011 Aug 23.
3
血清素2A（5-HT）受体信号改变是轻度创伤性脑损伤引发的社会优势缺陷的基础。
Front Pharmacol. 2022 Jul 15;13:930346. doi: 10.3389/fphar.2022.930346. eCollection 2022.
4
A combined therapeutic regimen of citalopram and environmental enrichment ameliorates attentional set-shifting performance after brain trauma.西酞普兰联合环境强化治疗可改善脑外伤后的注意定势转移表现。
Eur J Pharmacol. 2021 Aug 5;904:174174. doi: 10.1016/j.ejphar.2021.174174. Epub 2021 May 15.
5
Environmental enrichment and amantadine confer individual but nonadditive enhancements in motor and spatial learning after controlled cortical impact injury.环境丰富和金刚烷胺在皮质撞击损伤后分别但非累加地增强运动和空间学习能力。
Brain Res. 2019 Jul 1;1714:227-233. doi: 10.1016/j.brainres.2019.03.007. Epub 2019 Mar 12.
6
Spontaneous recovery of traumatic brain injury-induced functional deficits is not hindered by daily administration of lorazepam.每天服用劳拉西泮不会阻碍创伤性脑损伤所致功能缺陷的自发恢复。
Behav Brain Res. 2018 Feb 26;339:215-221. doi: 10.1016/j.bbr.2017.11.039. Epub 2017 Dec 2.
7
Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats.简化的环境富集对脑损伤雌性大鼠具有神经行为、认知和组织学方面的益处。
Exp Neurol. 2016 Dec;286:61-68. doi: 10.1016/j.expneurol.2016.09.015. Epub 2016 Sep 28.
8
Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury.靶向α7烟碱型乙酰胆碱受体：创伤性脑损伤神经保护的未来潜力。
Neural Regen Res. 2015 Oct;10(10):1552-4. doi: 10.4103/1673-5374.165309.
9
5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma.5-羟色胺1A（5-HT1A）受体激动剂：十年的实证证据支持将其用作脑外伤的有效治疗策略。
Brain Res. 2016 Jun 1;1640(Pt A):5-14. doi: 10.1016/j.brainres.2015.11.026. Epub 2015 Nov 21.
10
Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.翻译结果：实验性创伤性脑损伤的生物学与行为学理解。
Neurosci Biobehav Rev. 2015 Nov;58:123-46. doi: 10.1016/j.neubiorev.2014.12.004. Epub 2014 Dec 10.
Evaluation of a combined therapeutic regimen of 8-OH-DPAT and environmental enrichment after experimental traumatic brain injury.
实验性创伤性脑损伤后 8-OH-DPAT 与环境富集联合治疗方案的评价。
J Neurotrauma. 2010 Nov;27(11):2021-32. doi: 10.1089/neu.2010.1535. Epub 2010 Oct 28.
4
5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT(1A) receptor stimulation on contextual learning in mice.8-OH-DPAT对5-HT7受体的刺激可抵消5-HT(1A)受体刺激对小鼠情境学习的损害作用。
Eur J Pharmacol. 2008 Oct 31;596(1-3):107-10. doi: 10.1016/j.ejphar.2008.08.026. Epub 2008 Aug 29.
5
A delayed and chronic treatment regimen with the 5-HT1A receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning.在皮质撞击损伤后，使用5-羟色胺1A受体激动剂8-羟基二丙胺四乙酸进行延迟和长期治疗方案，有助于运动恢复和空间学习能力的获得。
Behav Brain Res. 2008 Dec 1;194(1):79-85. doi: 10.1016/j.bbr.2008.06.025. Epub 2008 Jul 1.
6
Synergistic effects of D1/5 and 5-HT1A/7 receptor agonists on locomotor movement induction in complete spinal cord-transected mice.D1/5与5-HT1A/7受体激动剂对完全脊髓横断小鼠运动诱导的协同作用。
J Neurophysiol. 2008 Jul;100(1):160-8. doi: 10.1152/jn.90339.2008. Epub 2008 May 14.
7
Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat.5-羟色胺（7）拮抗剂SB-269970对大鼠工作记忆和参考记忆调节的影响。
Behav Brain Res. 2008 Dec 16;195(1):164-70. doi: 10.1016/j.bbr.2007.12.020. Epub 2008 Jan 9.
8
5-HT(1A) receptors and memory.5-羟色胺（1A）受体与记忆。
Neurosci Biobehav Rev. 2007;31(5):705-27. doi: 10.1016/j.neubiorev.2007.02.001. Epub 2007 Feb 27.
9
The neurobehavioral benefit conferred by a single systemic administration of 8-OH-DPAT after brain trauma is confined to a narrow therapeutic window.脑外伤后单次全身给予8-OH-DPAT所带来的神经行为益处局限于一个狭窄的治疗窗。
Neurosci Lett. 2007 Apr 12;416(2):165-8. doi: 10.1016/j.neulet.2007.02.006. Epub 2007 Feb 7.
10
Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma.5-羟色胺（1A）受体激动剂8-羟基二丙胺四乙酸（8-OH-DPAT）的急性治疗和长期环境富集在实验性脑损伤后带来神经行为益处。
Behav Brain Res. 2007 Feb 27;177(2):186-94. doi: 10.1016/j.bbr.2006.11.036. Epub 2006 Dec 12.