脂联素基因多态性及其与2型糖尿病的关联。
Adiponectin gene polymorphism and its association with type 2 diabetes mellitus.
作者信息
Biswas Devadrita, Vettriselvi V, Choudhury Jnankumar, Jothimalar R
出版信息
Indian J Clin Biochem. 2011 Apr;26(2):172-7. doi: 10.1007/s12291-011-0123-5. Epub 2011 Apr 7.
Abstract
Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type 2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T > G of adiponectin gene and type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with 75 apparently healthy controls. The genotype frequency of SNP45 T > G in exon 2 of adiponectin gene was determined by PCR based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC↓GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp) and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T > G and type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312-10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for type 2 diabetes.
摘要
据报道，脂联素基因不同区域的突变与肥胖、动脉粥样硬化和2型糖尿病有关。本研究旨在调查南印度人群中脂联素基因SNP 45 T>G与2型糖尿病之间的关联。研究了75例临床诊断的2型糖尿病病例，并与75名明显健康的对照者进行比较。使用限制性内切酶SmaI（识别位点：CCC↓GGG），通过基于PCR的限制性酶切分析确定脂联素基因外显子2中SNP45 T>G的基因型频率。研究了三种基因型：野生型TT（470 bp）、杂合型TG（470 bp、336 bp、134 bp）和纯合突变型GG（336 bp、134 bp）。在研究人群中发现SNP45 T>G与2型糖尿病之间存在正相关（P = 0.010，OR = 3.797，95% CI = 1.312 - 10.983）。因此，脂联素基因中的SNP45T>G可能是2型糖尿病的危险因素之一。
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