Lüdtke F E, Schuff-Werner P, Lion K A, Speer C P
Department of General Surgery, University of Goettingen, West Germany.
J Surg Res. 1990 Nov;49(5):413-8. doi: 10.1016/0022-4804(90)90189-9.
Different immune functions were analysed in detail in 41 patients who had been splenectomized after a traumatic rupture of the spleen within four years after surgical intervention. Patients were assigned to one of the following groups as judged by liver/spleen scintigraphy: (1) patients with reimplanted splenic tissue, (2) patients with splenosis, and (3) patients without splenic tissue. Leukocytosis and an increased number of total lymphocytes as well as B-cells were observed in patients of all groups. In addition, the number of circulating T-suppressor cells was significantly increased in patients with no detectable splenic tissue. In contrast, serum concentrations of immunoglobulins and complement components were in the normal range; similarly, phagocytosis-associated functions of the patients' neutrophils and monocytes were found to be unimpaired (chemiluminescence and particle uptake). However, in all groups of splenectomized patients a deficiency in specific serum opsonic activity against a strain of Escherichia coli (O:102, H:6) could be detected. We conclude that neither splenosis nor autologous reimplantation of splenic tissue restores opsonic deficiency caused by splenectomy.
对41例在脾外伤性破裂后4年内接受脾切除术的患者的不同免疫功能进行了详细分析。根据肝/脾闪烁扫描结果，将患者分为以下几组：（1）脾组织再植入患者，（2）脾组织种植患者，（3）无脾组织患者。所有组的患者均观察到白细胞增多以及总淋巴细胞和B细胞数量增加。此外，在无可检测到脾组织的患者中，循环T抑制细胞的数量显著增加。相比之下，免疫球蛋白和补体成分的血清浓度在正常范围内；同样，发现患者中性粒细胞和单核细胞的吞噬相关功能未受损（化学发光和颗粒摄取）。然而，在所有脾切除患者组中，均检测到针对一株大肠杆菌（O:102，H:6）的特异性血清调理活性缺乏。我们得出结论，脾组织种植和脾组织自体再植入均不能恢复脾切除引起的调理缺陷。
