性病研究实验室试验及其解读。
VDRL test and its interpretation.
作者信息
Nayak Surajit, Acharjya Basanti
机构信息
Department of Skin and VD, MKCG Medical College and Hospital, Berhampur, Orissa, India.
出版信息
Indian J Dermatol. 2012 Jan;57(1):3-8. doi: 10.4103/0019-5154.92666.
Abstract
Venereal disease research laboratory (VDRL) test is a nontreponemal test, used for screening of syphilis due to its simplicity, sensitivity and low cost. Prozone phenomenon and biological false positive (BFP) reaction are two shortcomings of this test. Quantitative estimation of VDRL is essential in treatment evaluation. CSF VDRL test is very specific for neurosyphilis though its sensitivity is low. Interpretation of VDRL in HIV infection is incompletely understood.
摘要
性病研究实验室（VDRL）试验是一种非梅毒螺旋体试验，因其操作简单、灵敏度高且成本低，用于梅毒筛查。前带现象和生物学假阳性（BFP）反应是该试验的两个缺点。VDRL定量评估在治疗评估中至关重要。脑脊液VDRL试验对神经梅毒非常特异，尽管其灵敏度较低。HIV感染中VDRL的解读尚不完全清楚。
相似文献
1
VDRL test and its interpretation.性病研究实验室试验及其解读。
Indian J Dermatol. 2012 Jan;57(1):3-8. doi: 10.4103/0019-5154.92666.
2
Biological false-positive venereal disease research laboratory test in cerebrospinal fluid in the diagnosis of neurosyphilis - a case-control study.生物假阳性性病研究实验室试验在脑脊液中的神经梅毒诊断-病例对照研究。
J Eur Acad Dermatol Venereol. 2018 Mar;32(3):474-481. doi: 10.1111/jdv.14681. Epub 2017 Dec 6.
3
Biological false-positive tests comprise a high proportion of Venereal Disease Research Laboratory reactions in an analysis of 300,000 sera.在对30万份血清的分析中，生物学假阳性检测在性病研究实验室反应中占很高比例。
Int J STD AIDS. 2005 Nov;16(11):722-6. doi: 10.1258/095646205774763207.
4
Seroprevalence of syphilis by VDRL test and biological false positive reactions in different patient populations: Is it alarming? Our experience from a tertiary care center in India.不同患者群体中梅毒血清学阳性率（通过性病研究实验室试验检测）及生物学假阳性反应：情况令人担忧吗？我们来自印度一家三级医疗中心的经验。
Indian J Sex Transm Dis AIDS. 2020 Jan-Jun;41(1):43-46. doi: 10.4103/0253-7184.194317. Epub 2016 Nov 17.
5
The optimum condition of the toluidine red unheated serum test for the replacement of the venereal disease research laboratory test in cerebrospinal fluid for neurosyphilis diagnosis.甲苯胺红不加热血清试验替代性病研究实验室脑脊液试验用于神经梅毒诊断的最佳条件。
Heliyon. 2023 Jun 12;9(6):e17157. doi: 10.1016/j.heliyon.2023.e17157. eCollection 2023 Jun.
6
The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis.快速血浆反应素试验不能替代性病研究实验室试验用于神经梅毒的诊断。
Sex Transm Dis. 2012 Jun;39(6):453-7. doi: 10.1097/OLQ.0b013e31824b1cde.
7
Which Is the Optimum Antigen Concentration for the Venereal Disease Research Laboratory Test of Cerebrospinal Fluid for Neurosyphilis Diagnosis: 10 or 17 μL?用于神经梅毒诊断的脑脊液性病研究实验室检测的最佳抗原浓度是多少：10μL还是17μL？
Front Med (Lausanne). 2022 Apr 28;9:877186. doi: 10.3389/fmed.2022.877186. eCollection 2022.
8
Evaluation of VDRL test in Sudanese blood donors.苏丹献血者中梅毒血清学试验（VDRL）的评估
Trop Doct. 1982 Apr;12(2):61-2. doi: 10.1177/004947558201200205.
9
Biological false positive serological tests for syphilis in the Jamaican population.牙买加人群中梅毒血清学检测的生物学假阳性
Genitourin Med. 1990 Apr;66(2):76-8. doi: 10.1136/sti.66.2.76.
10
Enzyme-linked immunosorbent assay for detection of antibodies to the venereal disease research laboratory (VDRL) antigen in syphilis.用于检测梅毒中针对性病研究实验室（VDRL）抗原抗体的酶联免疫吸附测定。
J Clin Microbiol. 1987 Sep;25(9):1711-6. doi: 10.1128/jcm.25.9.1711-1716.1987.
引用本文的文献
1
Neurosyphilis: Discussing the Diagnostic Challenges.神经梅毒：探讨诊断挑战
Clin Case Rep. 2025 May 9;13(5):e70504. doi: 10.1002/ccr3.70504. eCollection 2025 May.
2
Study Protocol for a Yoga-Based Lifestyle Modification Program for Leucorrhea Disorders.基于瑜伽的白带异常生活方式改善计划研究方案。
Cureus. 2025 Jan 31;17(1):e78294. doi: 10.7759/cureus.78294. eCollection 2025 Jan.
3
Otosyphilis: A Rare Case of Unilateral Acute Sensorineural Hearing Loss.耳梅毒：一例罕见的单侧急性感音神经性听力损失病例。
Cureus. 2025 Jan 12;17(1):e77338. doi: 10.7759/cureus.77338. eCollection 2025 Jan.
4
The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients.一种针对HIV阴性患者的新型神经梅毒诊断标准的性能。
Sci Rep. 2024 Dec 28;14(1):31171. doi: 10.1038/s41598-024-82477-6.
5
A Loop-Mediated Isothermal Amplification Assay Utilizing Hydroxy Naphthol Blue (LAMP-HNB) for the Detection of Subspp. .一种利用羟基萘酚蓝的环介导等温扩增检测法（LAMP-HNB）用于检测亚种。
Pathogens. 2024 Oct 31;13(11):949. doi: 10.3390/pathogens13110949.
6
Prevalence of Transfusion-Transmissible Infections Among Voluntary Blood Donors in a Tertiary Care Hospital.三级护理医院中自愿献血者输血传播感染的患病率
Cureus. 2024 Sep 29;16(9):e70469. doi: 10.7759/cureus.70469. eCollection 2024 Sep.
7
Changes in the HIV Epidemic in Lower Silesia, Poland, Between 2010 and 2020: The Characteristics of the Key Populations.2010 年至 2020 年期间波兰下西里西亚艾滋病疫情变化：重点人群特征。
Viruses. 2024 Sep 11;16(9):1445. doi: 10.3390/v16091445.
8
Comparing stem cells, transdifferentiation and brain organoids as tools for psychiatric research.比较干细胞、转分化和脑类器官作为精神疾病研究工具。
Transl Psychiatry. 2024 Feb 28;14(1):127. doi: 10.1038/s41398-024-02780-8.
9
A rare case of syphilitic Charcot joint involving left elbow.一例罕见的累及左肘部的梅毒性夏科关节病例。
Indian J Sex Transm Dis AIDS. 2023 Jul-Dec;44(2):175-177. doi: 10.4103/ijstd.IJSTD_21_20. Epub 2023 Dec 6.
10
The Continued Rise of Syphilis: A Case Report to Aid in Identification of the Great Imitator.梅毒的持续上升：一则有助于识别“伟大模仿者”的病例报告
J Educ Teach Emerg Med. 2023 Apr 30;8(2):V11-V15. doi: 10.21980/J8KM02. eCollection 2023 Apr.
本文引用的文献
1
Biological false reactive VDRL tests: when to re-test?生物学假阳性VDRL试验：何时重新检测？
Southeast Asian J Trop Med Public Health. 2002;33 Suppl 3:131-2.
2
False-positive reaction to VDRL test with prozone phenomena. Association with lymphosarcoma.
JAMA. 1966 Mar 7;195(10):868-9. doi: 10.1001/jama.1966.03100100120044.
3
Sexually transmitted diseases treatment guidelines 2002. Centers for Disease Control and Prevention.《2002年性传播疾病治疗指南》。疾病控制与预防中心。
MMWR Recomm Rep. 2002 May 10;51(RR-6):1-78.
4
Syphilis. Serology.梅毒。血清学。
Dermatol Clin. 1998 Oct;16(4):691-8. doi: 10.1016/s0733-8635(05)70034-6.
5
Syphilis serology in human immunodeficiency virus infection: evidence for false-negative fluorescent treponemal testing.人类免疫缺陷病毒感染中的梅毒血清学：梅毒螺旋体荧光试验假阴性的证据。
J Infect Dis. 1997 Nov;176(5):1397-400. doi: 10.1086/517330.
6
A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group.一项针对合并或未合并人类免疫缺陷病毒感染的早期梅毒患者强化治疗的随机试验。梅毒与艾滋病毒研究小组。
N Engl J Med. 1997 Jul 31;337(5):307-14. doi: 10.1056/NEJM199707313370504.
7
Sexual transmission of HIV.艾滋病毒的性传播。
N Engl J Med. 1997 Apr 10;336(15):1072-8. doi: 10.1056/NEJM199704103361507.
8
Incidence of the prozone phenomenon in syphilis serology.梅毒血清学中前带现象的发生率。
Obstet Gynecol. 1994 Oct;84(4):609-12.
9
Biological false-positive syphilis test results for women infected with human immunodeficiency virus.感染人类免疫缺陷病毒的女性梅毒检测结果出现生物学假阳性。
Clin Infect Dis. 1994 Dec;19(6):1040-4. doi: 10.1093/clinids/19.6.1040.
10
Laboratory diagnosis and interpretation of tests for syphilis.梅毒检测的实验室诊断与解读
Clin Microbiol Rev. 1995 Jan;8(1):1-21. doi: 10.1128/CMR.8.1.1.
Zotero 插件