Gecit Ilhan, Kavak Servet, Demir Halit, Gunes Mustafa, Pirincci Necip, Cetin Cigdem, Ceylan Kadir, Benli Erdal, Yildiz Ibrahim
Department of Urology, Division of Biochemistry, Yuzuncu Yil University, Van, Turkey.
Asian Pac J Cancer Prev. 2011;12(12):3409-13.
Trace elements are essential components of biological structures, but they can be toxic at concentrations beyond those necessary for their biological functions. In the present study, groups of 35 patients with bladder cancer and 34 healthy volunteer controls were measured for trace elements using a furnace atomic absorption spectrophotometer. Serum levels of Cd, Ni and Co were increased (p<0.05) and Mn and Zn were decreased (p<0.05) in patients with bladder cancer. In the present study, a relationship was seen between the level of trace elements and the occurrence of bladder cancer, suggesting that an increase in the serum level of Cd, Ni, Co and a decrease in the levels of Zn and Mn might be important causes of bladder cancer occurrence; however, defining such a cause-and-effect relationship needs several prospective studies to be done, which seems necessary with regard to the high prevalence of this cancer.
微量元素是生物结构的重要组成部分，但当浓度超过其生物功能所需水平时，它们可能具有毒性。在本研究中，使用火焰原子吸收分光光度计对35例膀胱癌患者和34名健康志愿者对照组进行了微量元素检测。膀胱癌患者血清中的镉、镍和钴水平升高（p<0.05），而锰和锌水平降低（p<0.05）。在本研究中，观察到微量元素水平与膀胱癌的发生之间存在关联，这表明血清中镉、镍、钴水平的升高以及锌和锰水平的降低可能是膀胱癌发生的重要原因；然而，要确定这种因果关系需要进行多项前瞻性研究，鉴于这种癌症的高发病率，这似乎是必要的。
