Rafieemehr Hassan, Kamyari Naser, Maleki Behzad Masumeh
Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Biostatistics and Epidemiology, School of Health, Abadan University of Medical Sciences, Abadan, Iran.
Heliyon. 2024 Jun 25;10(13):e33620. doi: 10.1016/j.heliyon.2024.e33620. eCollection 2024 Jul 15.
Trace elements (TEs) have electrochemical and catalytic effects and play a crucial role in metabolism. A change in the concentrations of specific TEs may be associated with the incidence of various diseases such as solid tumors and hematological malignancies. By comparing the concentrations of TEs in the cases and controls, this study aims to provide insights into the possible impacts of TEs concentration on the incidence of leukemia and lymphoma.
In the current study, the serum concentrations of Zn, Cu, Cd, Fe, and Se were analyzed for 20 patients with leukemia and lymphoma and 20 healthy individuals. Those concentrations were measured by atomic absorption spectroscopy.
The serum Zn concentration in the cases was significantly lower than that in the controls (P < 0.05). The serum concentrations of Cu, Cd and Fe were also lower in the cases than in the controls. However, no significant difference was found (P > 0.05). Also, the serum concentration of Se was higher in the patients than in the controls, but no significant difference was found (P > 0.05).
The results indicate that a low serum concentration of Zn may be associated with the incidence of leukemia and lymphoma. The assessment of TEs in hematological malignancies may be of a prognostic value and provide knowledge about the side effects of alterations in the concentration of those elements. It may also lead to the use of suitable strategies to better manage the clinical conditions of patients.
微量元素具有电化学和催化作用，在新陈代谢中起着至关重要的作用。特定微量元素浓度的变化可能与各种疾病的发生有关，如实体瘤和血液系统恶性肿瘤。通过比较病例组和对照组中微量元素的浓度，本研究旨在深入了解微量元素浓度对白血病和淋巴瘤发病率的可能影响。
在本研究中，分析了20例白血病和淋巴瘤患者及20名健康个体的血清锌、铜、镉、铁和硒浓度。这些浓度通过原子吸收光谱法测量。
病例组血清锌浓度显著低于对照组（P < 0.05）。病例组血清铜、镉和铁浓度也低于对照组。然而，未发现显著差异（P > 0.05）。此外，患者血清硒浓度高于对照组，但未发现显著差异（P > 0.05）。
结果表明血清锌浓度低可能与白血病和淋巴瘤的发病有关。对血液系统恶性肿瘤中微量元素的评估可能具有预后价值，并提供有关这些元素浓度改变的副作用的知识。它还可能导致采用合适的策略来更好地管理患者的临床状况。
