Uaboonkul Thanatsuda, Nakakes Artit, Ayuthaya Pinyapat Kanechorn Na
Dermatology, Phramongkutklao Hospital, Bangkok, Thailand.
J Cosmet Laser Ther. 2012 Jun;14(3):145-9. doi: 10.3109/14764172.2012.682066.
Post-inflammatory hyperpigmentation (PIH) after laser treatment of Hori nevus remains problematic. Prevention and treatment of PIH have limited success.
To study the effects on hyperpigmentation using topical antibiotic alone versus combined antibiotic and betamethasone/valerate after 1064 nm Q-switched Nd:YAG laser treatment of Hori nevus.
Twenty-five cases of Hori nevus treated with Q-switched Nd:YAG laser randomly applied topical fucidic acid (control group) or fucidic acid plus betamethasone/valerate (study group) on assigned cheek immediately post laser for 2 weeks. Pigmentation was measured using the mexameter as melanin index (MI) and erythema index (EI), at baseline, 2nd and 4th weeks. Photographic evaluation and patient global assessment were done at the 4th week.
Twenty-three cases completed the study. No patient developed side effect from either creams. The comparison of M and E-indexes of the control versus the study group revealed no significant difference. However, there was a uniform increase of M index of the control group compared to the study group.
Applying topical corticosteroid immediately after laser treatment decreased pigmentation. Although not statistically significant, there was a tendency for lightening. Future studies are needed with more patients, duration of follow-ups and histological studies to assess pigmentary changes.
激光治疗太田痣后炎症后色素沉着（PIH）仍然是个问题。PIH的预防和治疗成效有限。
研究1064nm调Q Nd:YAG激光治疗太田痣后单独使用外用抗生素与联合使用抗生素和倍他米松/戊酸酯对色素沉着的影响。
25例太田痣患者接受调Q Nd:YAG激光治疗，随机在激光治疗后立即在指定脸颊上外用夫西地酸（对照组）或夫西地酸加倍他米松/戊酸酯（研究组），持续2周。在基线、第2周和第4周使用黑色素仪测量色素沉着，以黑色素指数（MI）和红斑指数（EI）表示。在第4周进行摄影评估和患者整体评估。
23例患者完成研究。两组患者均未出现乳膏的副作用。对照组与研究组的M指数和E指数比较无显著差异。然而，与研究组相比，对照组的M指数有一致的升高。
激光治疗后立即外用糖皮质激素可减少色素沉着。虽然无统计学意义，但有色素减轻的趋势。未来需要更多患者、更长随访时间和组织学研究来评估色素变化。
