酚类和羟基苯乙烯衍生物的区域选择性酶羧化。
Regioselective enzymatic carboxylation of phenols and hydroxystyrene derivatives.
机构信息
Austrian Centre of Industrial Biotechnology, University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
出版信息
Org Lett. 2012 Apr 20;14(8):1974-7. doi: 10.1021/ol300385k. Epub 2012 Apr 3.
Abstract
The enzymatic carboxylation of phenol and styrene derivatives using (de)carboxylases in carbonate buffer proceeded in a highly regioselective fashion: Benzoic acid (de)carboxylases selectively formed o-hydroxybenzoic acid derivatives, phenolic acid (de)carboxylases selectively acted at the β-carbon atom of styrenes forming (E)-cinnamic acids.
摘要
使用碳酸缓冲液中的（去）羧化酶对苯酚和苯乙烯衍生物进行酶促羧化反应具有高度的区域选择性：苯甲酸（去）羧化酶选择性地形成邻羟基苯甲酸衍生物，酚酸（去）羧化酶选择性地作用于苯乙烯的β-碳原子，形成（E）-肉桂酸。
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