Department of Chemistry, University of California, Berkeley, California 94720, USA.
Org Lett. 2012 Apr 20;14(8):2110-3. doi: 10.1021/ol300647k. Epub 2012 Apr 3.
An efficient synthesis of the octahydro-1H-2,4-methanoindene core of phragmalin-type limonoids, such as xyloccensins O and P, is reported. The success of the synthetic route is predicated on the use of network analysis in the retrosynthetic analysis and a Diels-Alder reaction for the synthesis of a key hydrindanone derivative.
报道了法呢基丙酮型柠檬苦素类化合物，如 xyloccensins O 和 P 的八氢-1H-2,4-甲桥茚满核心的有效合成。该合成路线的成功依赖于在逆合成分析中使用网络分析和 Diels-Alder 反应合成关键的氢化茚酮衍生物。
