染色质状态遗传的机制。
Mechanisms for the inheritance of chromatin states.
机构信息
Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell. 2011 Aug 19;146(4):510-8. doi: 10.1016/j.cell.2011.07.013.
Abstract
Studies in eukaryotes ranging from yeast to mammals indicate that specific chromatin structures can be inherited following DNA replication via mechanisms acting in cis. Both the initial establishment of such chromatin structures and their inheritance require sequence-dependent specificity factors and changes in histone posttranslational modifications. Here I propose models for the maintenance of epigenetic information in which DNA silencers or nascent RNA scaffolds act as sensors that work cooperatively with parentally inherited histones to re-establish chromatin states following DNA replication.
摘要
真核生物（从酵母到哺乳动物）的研究表明，通过顺式作用机制，特定的染色质结构可以在 DNA 复制后遗传。这些染色质结构的最初建立及其遗传都需要序列依赖性的特异性因子和组蛋白翻译后修饰的变化。在这里，我提出了维持表观遗传信息的模型，其中 DNA 沉默子或新生 RNA 支架作为传感器，与亲本遗传的组蛋白协同作用，在 DNA 复制后重新建立染色质状态。
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