Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
Prostate. 2012 Nov;72(15):1622-7. doi: 10.1002/pros.22515. Epub 2012 Apr 2.
Amine catabolism by monoamine oxidase A (MAOA) contributes to oxidative stress, which plays a role in prostate cancer (PCa) development and progression. An upstream variable-number tandem repeat (uVNTR) in the MAOA promoter influences gene expression and activity, and may thereby affect PCa susceptibility.
Caucasian (n = 2,572) men from two population-based case-control studies of PCa were genotyped for the MAOA-VNTR. Logistic regression was used to assess PCa risk in relation to genotype.
Common alleles of the MAOA-VNTR were not associated with the relative risk of PCa, nor did the relationship differ by clinical features of the disease. The rare 5-copy variant (frequency: 0.5% in cases; 1.8% in controls), however, was associated with a reduced PCa risk (odds ratio, OR = 0.30, 95% CI 0.13-0.71).
A rare polymorphism of the MAOA promoter previously shown to confer low expression was associated with a reduced risk of developing PCa. This novel finding awaits confirmation in other study populations.
单胺氧化酶 A（MAOA）的胺类代谢产物会导致氧化应激，这在前列腺癌（PCa）的发生和发展中起着一定的作用。MAOA 启动子中的一个上游可变数串联重复（uVNTR）会影响基因表达和活性，从而可能会影响 PCa 的易感性。
对来自两项基于人群的 PCa 病例对照研究的 2572 名白种人男性进行 MAOA-VNTR 基因分型。采用 logistic 回归分析评估基因型与 PCa 风险之间的关系。
MAOA-VNTR 的常见等位基因与 PCa 的相对风险无关，与疾病的临床特征也没有关系。然而，罕见的 5 拷贝变异体（频率：病例组为 0.5%；对照组为 1.8%）与 PCa 风险降低相关（比值比，OR=0.30，95%CI 0.13-0.71）。
先前研究表明，MAOA 启动子的罕见多态性与低表达相关，与 PCa 发病风险降低有关。这一新颖的发现需要在其他研究人群中得到证实。
