洞悉激动剂 cinaciguat 对氧化型可溶性鸟苷酸环化酶的解救作用。
Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.
机构信息
QB3 Institute, University of California, Berkeley, CA 94720, USA.
出版信息
Chembiochem. 2012 May 7;13(7):977-81. doi: 10.1002/cbic.201100809. Epub 2012 Mar 30.
Abstract
Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.
摘要
一氧化氮（NO）信号通过受体可溶性鸟苷酸环化酶（sGC）介导许多重要的生理过程。在疾病条件下，sGC 的血红素可以被氧化，导致 NO 不敏感。在这里，我们表明治疗化合物西那卡塞（Cin）通过直接置换氧化的血红素来拯救功能失调的 sGC。
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