Martínez-Luis Sergio, Cherigo Lilia, Arnold Elizabeth, Spadafora Carmenza, Gerwick William H, Cubilla-Rios Luis
Center for Drug Discovery, Institute for Advanced Scientific Research and High Technology Services, City of Knowledge, PO Box 0843-01103, Panama.
Nat Prod Commun. 2012 Feb;7(2):165-8.
With the combined goal of finding the best anti-parasitic and anti-cancer activities as well as isolating the bioactive agents and studying their structures and biological properties, we proceeded to perform a small-scale cultivation of Aspergillus sp. strain F1544 using Potato Dextrose, Malt Extract, Czapek Dox and Eight Vegetables media. From the more promising extracts (obtaining using potato dextrose and czapek dox media in large scale) of this fungus, we isolated the five compounds: pseurotin A (1), 14-norpseurotin A (2), FD-838 (3), and pseurotin D (4), and fumoquinone B (5). All compounds showed good antileishmanial and moderate anticancer activities.
为了实现寻找最佳抗寄生虫和抗癌活性、分离生物活性剂并研究其结构和生物学特性的共同目标，我们着手使用马铃薯葡萄糖、麦芽提取物、察氏培养基和八种蔬菜培养基对曲霉属菌株F1544进行小规模培养。从这种真菌更有前景的提取物（大规模使用马铃薯葡萄糖和察氏培养基获得）中，我们分离出了五种化合物：伪轮枝菌素A（1）、14-去甲伪轮枝菌素A（2）、FD-838（3）、伪轮枝菌素D（4）和烟曲霉醌B（5）。所有化合物均表现出良好的抗利什曼原虫活性和中等的抗癌活性。
