Costa Emmanoel Vilaça, Dutra Lívia Macedo, Nogueira Paulo Cesar de Lima, Moraes Valéria Regina de Souza, Salvador Marcos José, Ribeiro Luis Henrique Gonzaga, Gadelha Fernanda Ramos
Department of Chemistry, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil 49100-000.
Nat Prod Commun. 2012 Feb;7(2):265-6.
The essential oil from the leaves of Annona vepretorun was obtained by hydrodistillation using a Clevenger-type apparatus and analyzed by GC-MS and GC-FID. Eighteen compounds representing 98.1% of the crude essential oil were identified. The major compounds identified were bicyclogermacrene (43.7%), spathulenol (11.4%), alpha-felandrene (10.0%), alpha-pinene (7.1%), (E)-beta-ocimene (6.8%), germacrene D (5.8%), and p-cymene (4.2%). The trypanocidal activity against Trypanosoma cruzi epimastigote forms, as well as, the antimicrobial and antioxidant proprieties was investigated. The essential oil showed a potent trypanocidal activity with IC50 value of 31.9 +/-1.3 microg x mL(-1). For antimicrobial activity, the best result was observed against Candida tropicalis with a MIC value of 100 microg x mL(-1). For antioxidant capacity the essential oil showed weak activity.
采用克利夫enger型装置通过水蒸馏法从番荔枝（Annona vepretorun）叶片中提取挥发油，并采用气相色谱 - 质谱联用仪（GC - MS）和气相色谱 - 火焰离子化检测器（GC - FID）进行分析。鉴定出了占粗挥发油98.1%的18种化合物。鉴定出的主要化合物有双环吉马烯（43.7%）、匙叶桉油烯醇（11.4%）、α-法呢烯（10.0%）、α-蒎烯（7.1%）、（E）-β-罗勒烯（6.8%）、吉马烯D（5.8%）和对伞花烃（4.2%）。研究了该挥发油对克氏锥虫前鞭毛体形式的杀锥虫活性以及抗菌和抗氧化特性。该挥发油表现出较强的杀锥虫活性，IC50值为31.9±1.3μg·mL-1。对于抗菌活性，对热带假丝酵母的效果最佳，MIC值为100μg·mL-1。该挥发油的抗氧化能力较弱。
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