Laboratory of Cardiovascular Physiotherapy, Nucleus of Research in Physical Exercise, Federal University of São Carlos (UFSCar), Via Washington Luiz, Km 235, São Carlos, SP 13565-905, Brazil.
Clin Auton Res. 2012 Aug;22(4):175-83. doi: 10.1007/s10286-012-0160-z. Epub 2012 Apr 3.
Coronary artery disease (CAD) and acute myocardial infarction (AMI) are associated with a reduction of heart rate variability (HRV). The aim of this study was to compare the HRV of CAD patients with and without AMI (CAD-AMI) with health-matched controls by linear (spectral analysis) and nonlinear [Shannon entropy (SE), conditional entropy (CE) and symbolic analysis (SA)] analysis.
Fifty-eight men were divided into three groups: healthy (n = 19, 57 ± 4 years), CAD (n = 20, 56 ± 10 years) and CAD-AMI (n = 19, 54 ± 12 years). The RR intervals were recorded at rest in the supine position for 10 min with an HR monitor (Polar(®)S810i). A series of 250 beats was selected to analyze variance, spectral analysis, SE, CE [complexity index (CI), normalized CI (NCI)] and SA (0V, 1V, 2LV and 2ULV patterns), as well as 0V (no significant variation) and 2ULV (two significant unlike variations), which reflect sympathetic and vagal modulation, respectively. One-way ANOVA (or the Kruskal-Wallis test when appropriate) and Pearson correlation were used.
The CAD group had higher body mass index and weight than the CAD-AMI group, but no differences were found between the healthy and AMI groups. There were no differences between the groups regarding linear and nonlinear analysis. The 0V and 2ULV patterns were significantly correlated with the SE, CI and NCI of the three groups.
There was no difference between the groups regarding cardiac autonomic modulation by linear and nonlinear methods, which may be due to beta-blocker use, coronary angioplasty and the exercise capacity of healthy subjects.
冠心病（CAD）和急性心肌梗死（AMI）与心率变异性（HRV）降低有关。本研究旨在通过线性（频谱分析）和非线性[香农熵（SE）、条件熵（CE）和符号分析（SA）]分析比较 CAD 伴 AMI（CAD-AMI）患者与健康匹配对照者的 HRV。
58 名男性分为三组：健康组（n=19，57±4 岁）、CAD 组（n=20，56±10 岁）和 CAD-AMI 组（n=19，54±12 岁）。使用 HR 监测器（Polar®S810i）在仰卧位休息时记录 10 分钟的 RR 间期。选择一系列 250 个心动周期来分析方差、频谱分析、SE、CE[复杂度指数（CI）、归一化 CI（NCI）]和 SA（0V、1V、2LV 和 2ULV 模式），以及 0V（无明显变化）和 2ULV（两个明显不同的变化），分别反映交感和迷走神经调节。使用单因素方差分析（或适当情况下的 Kruskal-Wallis 检验）和 Pearson 相关性。
CAD 组的体重指数和体重高于 CAD-AMI 组，但健康组和 AMI 组之间无差异。线性和非线性分析三组之间无差异。0V 和 2ULV 模式与 SE、CI 和 NCI 呈显著相关。
线性和非线性方法评估的心脏自主神经调节在三组之间无差异，这可能是由于使用了β受体阻滞剂、经皮冠状动脉介入治疗和健康受试者的运动能力。
