人类白细胞抗原与皮肤癌

HLA and skin cancer.

作者信息

Bonamigo Renan Rangel, Carvalho André Vicente Esteves de, Sebastiani Vanessa Raquel Zaleski, Silva Cristina Martino da, Pinto Angela Caroline de Zorzi

机构信息

Service of Dermatology, Federal University of Health Sciences of Porto Alegre, RS, Brazil.

出版信息

An Bras Dermatol. 2012 Jan-Feb;87(1):9-16; quiz 17-8. doi: 10.1590/s0365-05962012000100001.

DOI:10.1590/s0365-05962012000100001

PMID:22481646

Abstract

Skin cancer - melanoma and non melanoma - are common neoplasm with rising incidence over the last decades. It is an important public health problem. Its pathogenesis is not completely understood and the same happens with the genetic factors involved. The genes that encode the HLA are associated with some tumors and they may be responsible for one of the mechanisms that take part in the development of the before mentioned cancers. We have reviewed the literature on the subject of HLA antigens, melanoma and non melanoma skin cancer.

摘要

皮肤癌——黑色素瘤和非黑色素瘤——是常见的肿瘤，在过去几十年中发病率不断上升。这是一个重要的公共卫生问题。其发病机制尚未完全了解，涉及的遗传因素也是如此。编码人类白细胞抗原（HLA）的基因与某些肿瘤有关，它们可能是参与上述癌症发生的机制之一。我们回顾了关于HLA抗原、黑色素瘤和非黑色素瘤皮肤癌这一主题的文献。