Buense Roberta, Duarte Ida Alzira Gomes, Bouer Marcio
Irmandade da Santa Casa de Misericórdia de São Paulo, Brasil.
An Bras Dermatol. 2012 Jan-Feb;87(1):63-9. doi: 10.1590/s0365-05962012000100007.
Scleroderma is a chronic autoimmune disease characterized by progressive connective tissue sclerosis and microcirculatory changes. Localized scleroderma is considered a limited disease. However, in some cases atrophic and deforming lesions may be observed that hinder the normal development. Literature reports indicate phototherapy as a therapeutic modality with favorable response in cutaneous forms of scleroderma.
This study had the purpose of assessing the phototherapy treatment for localized scleroderma.
Patients with localized scleroderma were selected for phototherapy treatment. They were classified according to the type of localized scleroderma and evolutive stage of the lesions. Clinical examination and skin ultrasound were used to demonstrate the results thus obtained.
Some clinical improvement was observed after an average of 10 phototherapeutic sessions. All skin lesions were softer at clinical palpation with scores reduction upon pre and post treatment comparison. The ultrasound showed that most of the assessed lesions presented a decrease in dermal thickness, and only five maintained their previous measure. Treatment response was similar regardless of the type of phototherapeutic treatment employed.
The proposed treatment was effective for all lesions, regardless of the phototherapeutic modality employed. The improvement was observed in all treated skin lesions and confirmed by clinical evaluation and skin ultrasound.
硬皮病是一种慢性自身免疫性疾病，其特征为进行性结缔组织硬化和微循环改变。局限性硬皮病被认为是一种病情有限的疾病。然而，在某些情况下可能会观察到萎缩性和变形性病变，这会阻碍正常发育。文献报道表明光疗是一种对硬皮病皮肤型有良好反应的治疗方式。
本研究旨在评估局限性硬皮病的光疗效果。
选择局限性硬皮病患者进行光疗。根据局限性硬皮病的类型和病变的演变阶段对患者进行分类。采用临床检查和皮肤超声来展示所获得的结果。
平均进行10次光疗后观察到一些临床改善。所有皮肤病变在临床触诊时都更柔软，治疗前后比较评分降低。超声显示，大多数评估病变的真皮厚度减小，只有5个维持其先前的测量值。无论采用何种光疗方法，治疗反应相似。
无论采用何种光疗方式，所提出的治疗方法对所有病变均有效。在所有接受治疗的皮肤病变中均观察到改善，并通过临床评估和皮肤超声得到证实。
