Silveira Fábio Porto, Nicoluzzi João Eduardo, Saucedo Júnior Nestor Saucedo, Silveira Fábio, Nicollelli Guilherme Matiolli, Maranhão Bruno Souza De Albuquerque
Catholic University of Paraná, Brazil.
Rev Col Bras Cir. 2012;39(1):33-40. doi: 10.1590/s0100-69912012000100008.
To correlate serum preoperative and postoperative interleukin-6 and interleukin-10 levels in patients undergoing laparotomy versus laparoscopic cholecystectomy.
From a total of 20 patients, 18 were included in the study, nine underwent cholecystectomy by laparoscopy and the other nine by laparotomy. Serum concentrations of IL-6 and IL-10 were measured in both groups. Blood samples were obtained in the times of 24 hours preoperatively and four, 12 and 24 hours after the procedure. The groups were compared regarding age, gender, body mass index (BMI), duration of anesthesia and operation.
There was no significant statistical differences between groups related to age, gender, BMI, duration of anesthesia and operation. The comparison between the two procedurs demonstrated statistical differences for IL-6 in time 12 hours after operation (218.64 pg/ml laparotomic versus 67.71 pg/ml laparoscopic, p = 0.0003) and for IL-10 in time 24 hours after the procedure (24.46 pg/ml open versus 10.17 pg/qml laparoscopic, p <0.001).
There was an Increase in plasma levels of interleukin-6 and 10 after surgical trauma with a significant increase in levels of interleukins in the laparotomic group in comparison with the laparoscopic group.
比较接受剖腹手术与腹腔镜胆囊切除术患者术前和术后血清白细胞介素-6及白细胞介素-10水平的相关性。
在总共20例患者中，18例纳入研究，其中9例行腹腔镜胆囊切除术，另外9例行剖腹手术。两组均检测血清IL-6和IL-10浓度。于术前24小时以及术后4、12和24小时采集血样。比较两组患者的年龄、性别、体重指数（BMI）、麻醉和手术持续时间。
两组在年龄、性别、BMI、麻醉和手术持续时间方面无显著统计学差异。两种手术方式比较显示，术后12小时IL-6有统计学差异（剖腹手术组为218.64 pg/ml，腹腔镜手术组为67.71 pg/ml，p = 0.0003），术后24小时IL-10有统计学差异（开腹手术组为24.46 pg/ml，腹腔镜手术组为10.17 pg/ml，p <0.001）。
手术创伤后血浆白细胞介素-6和10水平升高，与腹腔镜手术组相比，剖腹手术组白细胞介素水平显著升高。
