Maruszynski M, Pojda Z
Department of Surgery, Institute of Surgery CSK WAM, Warsaw, Poland.
Surg Endosc. 1995 Aug;9(8):882-5. doi: 10.1007/BF00768883.
Interleukin 6 (IL-6) is involved in the processes of inflammation and tissue repair. We have been looking for the correlation between IL-6 concentration in patient's serum and the other factors related to the gravity of surgical trauma. Out of 25 patients with acute cholecystitis, 11 were randomly selected for laparoscopic cholecystectomy and the other 14 for open (laparotomic) cholecystectomy. The diagnostic and prognostic factors, age, and duration of disease did not differ significantly in either group. IL-6 serum levels were monitored by using commercially available ELISA tests throughout 72 h following the surgery. In patients who underwent laparoscopy, average IL-6 serum levels were significantly (up to fourfold) lower than in their laparotomy-treated counterparts, and the monitoring of IL-6 serum levels seems to be useful in the evaluation of the extent of trauma caused by surgery.
白细胞介素6（IL-6）参与炎症和组织修复过程。我们一直在寻找患者血清中IL-6浓度与其他与手术创伤严重程度相关因素之间的相关性。在25例急性胆囊炎患者中，随机选择11例行腹腔镜胆囊切除术，另外14例行开腹（剖腹）胆囊切除术。两组患者的诊断和预后因素、年龄及病程差异均无统计学意义。术后72小时内使用市售酶联免疫吸附测定（ELISA）试验监测IL-6血清水平。接受腹腔镜手术的患者，其平均IL-6血清水平显著低于接受剖腹手术的患者（高达四倍），监测IL-6血清水平似乎有助于评估手术造成的创伤程度。
