内体中囊泡的形成：内体分选转运复合体标记位点。
Vesicle formation within endosomes: An ESCRT marks the spot.
作者信息
Mayers Jonathan R, Audhya Anjon
机构信息
Department of Biomolecular Chemistry; University of Wisconsin-Madison Medical School; Madison, WI USA.
出版信息
Commun Integr Biol. 2012 Jan 1;5(1):50-6. doi: 10.4161/cib.18208.
Abstract
Vesicle-mediated cargo transport within the endomembrane system requires precise coordination between adaptor molecules, which recognize sorting signals on substrates, and factors that promote changes in membrane architecture. At endosomal compartments, a set of protein complexes collectively known as the ESCRT machinery sequesters transmembrane cargoes that harbor a ubiquitin modification and packages them into vesicles that bud into the endosome lumen. Several models have been postulated to describe this process. However, consensus in the field remains elusive. Here, we discuss recent findings regarding the structure and function of the ESCRT machinery, highlighting specific roles for ESCRT-0 and ESCRT-III in regulating cargo selection and vesicle formation.
摘要
内膜系统中囊泡介导的货物运输需要衔接分子（识别底物上的分选信号）与促进膜结构变化的因子之间精确协调。在内体区室，一组统称为ESCRT机制的蛋白质复合物隔离带有泛素修饰的跨膜货物，并将它们包装到向内体腔中出芽的囊泡中。已经提出了几种模型来描述这一过程。然而，该领域仍未达成共识。在这里，我们讨论了关于ESCRT机制的结构和功能的最新发现，强调了ESCRT-0和ESCRT-III在调节货物选择和囊泡形成中的特定作用。
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本文引用的文献
1
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J Biol Chem. 2011 Nov 18;286(46):40276-86. doi: 10.1074/jbc.M111.283671. Epub 2011 Sep 16.
2
Association of the endosomal sorting complex ESCRT-II with the Vps20 subunit of ESCRT-III generates a curvature-sensitive complex capable of nucleating ESCRT-III filaments.
J Biol Chem. 2011 Sep 30;286(39):34262-70. doi: 10.1074/jbc.M111.266411. Epub 2011 Aug 11.
3
The ESCRT pathway.
Dev Cell. 2011 Jul 19;21(1):77-91. doi: 10.1016/j.devcel.2011.05.015.
4
UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.
Curr Biol. 2011 Jul 26;21(14):1245-50. doi: 10.1016/j.cub.2011.06.028. Epub 2011 Jul 14.
5
Host factors involved in retroviral budding and release.
Nat Rev Microbiol. 2011 Jun 16;9(7):519-31. doi: 10.1038/nrmicro2596.
6
Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments.
Science. 2011 Mar 25;331(6024):1616-20. doi: 10.1126/science.1201847. Epub 2011 Feb 10.
7
ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously.
J Biol Chem. 2011 Mar 18;286(11):9636-45. doi: 10.1074/jbc.M110.185363. Epub 2010 Dec 30.
8
Influenza virus M2 protein mediates ESCRT-independent membrane scission.
Cell. 2010 Sep 17;142(6):902-13. doi: 10.1016/j.cell.2010.08.029.
9
Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition.
J Biol Chem. 2010 Nov 12;285(46):35428-38. doi: 10.1074/jbc.M110.126318. Epub 2010 Aug 30.
10
Structural role of the Vps4-Vta1 interface in ESCRT-III recycling.
Structure. 2010 Aug 11;18(8):976-84. doi: 10.1016/j.str.2010.04.014.
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