病毒性肝炎：加拿大一家儿科医院的回顾性研究
Viral hepatitis: retrospective review in a canadian pediatric hospital.
作者信息
Cybulska Paulina, Ni Andy, Jimenez-Rivera Carolina
机构信息
Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5.
出版信息
ISRN Pediatr. 2011;2011:182964. doi: 10.5402/2011/182964. Epub 2010 Dec 29.
Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of children diagnosed with viral hepatitis at our institution from January 1, 1998, to December 31, 2007. Results. There were 261 charts reviewed, only 64 had a confirmed viral etiology: 34 (53%) hepatitis B (HBV), 16 (25%) hepatitis C (HCV), 4 (6.3%) hepatitis A (HAV), 7 (11%) cytomegalovirus (CMV), and 3 (4.7%) Epstein-Barr virus (EBV). Children with HBV presented at a mean age of 6.4 ± 4.6 years. Spontaneous seroconversion (appearance of HBVeAb and loss of HBVeAg) occurred in 21/34 (61.7%). Children with acute hepatitis (HAV, CMV, and EBV) presented with mild abdominal pain, jaundice, and fevers. Overall outcome was excellent. Conclusion. Acute and chronic hepatitis in children has a benign course; moreover, HBV spontaneous seroconversion is common in pediatric patients.
引言。病毒性肝炎的临床表现从轻微症状到暴发性肝炎不等。我们的目的是描述加拿大安大略省东部/魁北克省西部地区病毒性肝炎患儿的临床表现和预后。方法。对1998年1月1日至2007年12月31日在我们机构被诊断为病毒性肝炎的患儿进行回顾性病历审查。结果。共审查了261份病历，只有64份确诊为病毒病因：34例（53%）为乙型肝炎（HBV），16例（25%）为丙型肝炎（HCV），4例（6.3%）为甲型肝炎（HAV），7例（11%）为巨细胞病毒（CMV），3例（4.7%）为EB病毒（EBV）。HBV患儿的平均发病年龄为6.4±4.6岁。21/34例（61.7%）出现自发血清学转换（出现HBVeAb且HBVeAg消失）。急性肝炎（HAV、CMV和EBV）患儿表现为轻度腹痛、黄疸和发热。总体预后良好。结论。儿童急性和慢性肝炎病程良性；此外，HBV自发血清学转换在儿科患者中很常见。
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