Rao Sirish C, Ashraf Imran, Mir Fazia, Samiullah Sami, Ibdah Jamal A, Tahan Veysel
Department of Internal Medicine, University of Missouri Hospital , Columbia, MO, USA.
Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, USA.
Am J Case Rep. 2017 Feb 16;18:170-172. doi: 10.12659/ajcr.901688.
BACKGROUND Hepatitis B virus (HBV) has been reported as a coinfection with hepatitis C virus (HCV), hepatitis D virus (HDV), cytomegalovirus (CMV), and human immunodeficiency virus (HIV). CASE REPORT A 34-year-old female presented to our clinic with epigastric pain and severe acute hepatitis manifested as jaundice associated with hyperbilirubinemia, elevated transaminases, and coagulopathy. The patient was diagnosed with acute HBV with Epstein-Barr virus (EBV) coinfection leading to subsequent chronic hepatitis B. CONCLUSIONS To our knowledge, this patient case is the first reported case of HBV and EBV coinfection reported in the literature. HBV and EBV coinfection may cause severe acute hepatitis with HBV chronicity.
背景 据报道，乙型肝炎病毒（HBV）可与丙型肝炎病毒（HCV）、丁型肝炎病毒（HDV）、巨细胞病毒（CMV）和人类免疫缺陷病毒（HIV）合并感染。病例报告 一名34岁女性因上腹部疼痛和严重急性肝炎前来我院就诊，表现为黄疸伴高胆红素血症、转氨酶升高和凝血功能障碍。该患者被诊断为急性HBV与爱泼斯坦-巴尔病毒（EBV）合并感染，随后发展为慢性乙型肝炎。结论 据我们所知，该病例是文献中首次报道的HBV与EBV合并感染病例。HBV与EBV合并感染可能导致严重的急性肝炎并发展为慢性HBV感染。
